Copper-Catalyzed C-N Bond Formation with N-Heterocycles and Aryl Halides

被引：24

作者：

Boswell, Mikki G. ^{[1
]}

Yeung, Fanny G. ^{[1
]}

Wolf, Christian ^{[1
]}

机构：

[1] Georgetown Univ, Dept Chem, Washington, DC 20057 USA

来源：

SYNLETT | 2012年 / 08期

基金：

美国国家科学基金会;

关键词：

copper; cross-coupling; N-heterocycles; aryl halides; microwave; CROSS-COUPLING REACTIONS; NITROGEN-CONTAINING HETEROCYCLES; LONG-LIVED CATALYSTS; ROOM-TEMPERATURE; AMINO-ACID; PALLADIUM PRECATALYSTS; EFFICIENT CATALYST; ARYLBORONIC ACID; HIGHLY EFFICIENT; AQUEOUS AMMONIA;

D O I：

10.1055/s-0031-1290827

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The microwave-assisted, cuprous oxide catalyzed coupling of aryl bromides and iodides with imidazole, benzimidazole, pyrazole, or triazole was found to give a wide range of N-aryl heteroaromatic products in good to high yields. Aryl dibromides undergo selective monosubstitution even in the presence of large excess of N-heterocyclic nucleophiles which leaves the second aryl bromide functionality intact for further derivatization.

引用

页码：1240 / 1244

页数：5

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