Copper-Catalyzed Tandem C-N Bond Formation Reaction: Selective Synthesis of 2-(Trifluoromethyl)benzimidazoles

被引：23
|
作者：
Chen, Mu-Wang [1 ]
Zhang, Xing-Guo [1 ]
Zhong, Ping [1 ]
Hu, Mao-Lin [1 ]
机构：
[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325027, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2009年 / 09期
基金：
中国国家自然科学基金;
关键词：
copper; double amination; N-(2-haloaryl)trifluoroacetimidoyl chlorides; primary amines; benzimidazoles; ONE-POT SYNTHESIS; EFFICIENT SYNTHESIS; REGIOSPECIFIC SYNTHESIS; COUPLING REACTIONS; ARYL HALIDES; ARYLATION; BENZIMIDAZOLE; ULLMANN; AMINES; ROUTE;
D O I：
10.1055/s-0028-1088160
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly practical method for the Synthesis Of fluorinated benzimidazoles was developed by Cul/TMEDA-catalyzed cross-coupling reaction of N-(2-haloaryl)trifluoroacetimidoyl chlorides with primary amines. The present double amination process tolerates the presence of Cl, Br, or I substituent at the 2-position of the phenyl group.
引用
收藏
页码：1431 / 1436
页数：6
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