A Cascade Dehydrogenative Cross-Coupling/Annulation Reaction of Benzamides with β-Keto Esters for the Synthesis of Isoquinolinone Derivatives

被引：26

作者：

Xu, Guo-Dong ^{[1
]}

Huang, Zhi-Zhen ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310028, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 23期

基金：

中国国家自然科学基金;

关键词：

BONDS; ETHERS;

D O I：

10.1021/acs.orglett.7b02978

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel cascade DCC/annulation reaction of N-alkoxybenzamides with beta-keto esters has been developed for the synthesis of isoquinolinone derivatives under palladium catalysis. A plausible mechanism involving alpha-C(sp(2))-H activation and a Pd(II)/Pd(IV) catalytic cycle is also proposed.

引用

页码：6265 / 6267

页数：3

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