Synthesis of N-alkoxyphthalimide derivatives via PIDA-promoted cross dehydrogenative coupling reaction

被引：7

作者：

Chen, Rongxiang ^{[1
]}

Liu, Bing ^{[2
]}

Li, Wenbo ^{[2
]}

Wang, Kai-Kai ^{[1
]}

Miao, Changqing ^{[2
]}

Li, Zhizhuang ^{[2
]}

Lv, Yingjie ^{[3
]}

Liu, Lantao ^{[4
]}

机构：

[1] Xinxiang Univ, Sch Pharm, Xinxiang 453000, Henan, Peoples R China

[2] Xinxiang Univ, Sch Chem & Mat Engn, Xinxiang 453000, Henan, Peoples R China

[3] Xinxiang Tuoxin Pharmaceut Co Ltd, Xinxiang 453000, Henan, Peoples R China

[4] Shangqiu Normal Univ, Coll Chem & Chem Engn, Shangqiu 476000, Henan, Peoples R China

来源：

RSC ADVANCES | 2021年 / 11卷 / 14期

基金：

中国国家自然科学基金;

关键词：

Reaction intermediates;

D O I：

10.1039/d1ra00375e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A PIDA-promoted cross-dehydrogenative coupling reaction between N-hydroxyphthalimide (NHPI) and aryl ketones for efficient synthesis of N-alkoxyphthalimide products in moderate to good yields has been described. This methodology is distinguished by catalyst-free conditions, readily available starting materials, wide substrate scope and operational simplicity. In addition, a gram-scale reaction and synthetic transformation of the product into synthetically useful intermediates has been demonstrated.

引用

页码：8051 / 8054

页数：4

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