A Cascade Dehydrogenative Cross-Coupling/Annulation Reaction of Benzamides with β-Keto Esters for the Synthesis of Isoquinolinone Derivatives

被引：26
|
作者：
Xu, Guo-Dong [1 ]
Huang, Zhi-Zhen [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310028, Zhejiang, Peoples R China
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 23期
基金：
中国国家自然科学基金;
关键词：
BONDS; ETHERS;
D O I：
10.1021/acs.orglett.7b02978
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel cascade DCC/annulation reaction of N-alkoxybenzamides with beta-keto esters has been developed for the synthesis of isoquinolinone derivatives under palladium catalysis. A plausible mechanism involving alpha-C(sp(2))-H activation and a Pd(II)/Pd(IV) catalytic cycle is also proposed.
引用
收藏
页码：6265 / 6267
页数：3
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