Electrochemical dehydrogenative cross-coupling of two anilines: facile synthesis of unsymmetrical biaryls

被引：24
|
作者：
Luo, Mu-Jia [1 ,2 ]
Li, Yang [1 ,2 ]
Ouyang, Xuan-Hui [2 ]
Li, Jin-Heng [1 ,2 ,3 ]
He, De-Liang [1 ]
机构：
[1] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China
[2] Nanchang Hangkong Univ, Key Lab Jiangxi Prov Persistent Pollutants Contro, Nanchang 330063, Jiangxi, Peoples R China
[3] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 18期
基金：
中国国家自然科学基金;
关键词：
NONSTEROIDAL ANTIINFLAMMATORY DRUG; NONSYMMETRIC BIPHENOLS; DERIVATIVES; ARYLATION; PHENOLS; BONDS; CATALYST;
D O I：
10.1039/c9cc09879h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new, general ortho/para-selective anodic dehydrogenative cross-coupling of two aryl amines, naphthalen-2-amine derivatives and anilines, is described. This electrochemical protocol assembles a wide range of unsymmetrical biaryls in good to excellent yields under mild, additional-metal-catalyst-free, oxidant-free conditions with excellent selectivity, broad substrate scope, and wide functional group tolerance. This electrochemical technology is highlighted with facile incorporation of important pharmacophores into the resulting biaryls, and is applicable to the homocoupling of anilines for producing symmetrical biaryls.
引用
收藏
页码：2707 / 2710
页数：4
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