Monitoring Ion Beam Therapy With a Compton Camera: Simulation Studies of the Clinical Feasibility

被引：26
|
作者：
Fontana, M. [1 ]
Ley, J. -L. [1 ]
Dauvergne, D. [2 ]
Freud, N. [3 ]
Krimmer, J. [1 ]
Letang, J. M. [3 ]
Maxim, V. [3 ]
Richard, M. -H. [1 ]
Rinaldi, I. [1 ]
Testa, E. [1 ]
机构：
[1] Univ Claude Bernard Lyon 1, CNRS IN2P3, Inst Phys Nucl Lyon, Univ Lyon, F-69622 Villeurbanne, France
[2] Univ Grenoble Alpes, CNRS, LPSC IN2P3, Grenoble INP, F-38000 Grenoble, France
[3] Univ Claude Bernard Lyon 1, CREATIS UMR 5220 U1206, Univ Lyon, CNRS,Inserm,Ctr Leon Berard,INSA Lyon,UJM St Etie, F-69373 Lyon, France
来源：
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES | 2020年 / 4卷 / 02期
关键词：
Clinical applicability; Compton camera; ion therapy; prompt gamma (PG); IMAGE-RECONSTRUCTION; PROTON THERAPY; SLIT CAMERA; OPTIMIZATION; IRRADIATION; RESOLUTION; EMISSION; DESIGN;
D O I：
10.1109/TRPMS.2019.2933985
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
As more and more particle therapy centers are being built world-wide, there is increasing need in treatment monitoring methods, ideally in real time. This article investigates the clinical applicability of a Compton camera design by means of Monte Carlo simulations. The Compton camera performance has been studied with the simulation of point-like source and beam irradiation of a polymethyl methacrylate (PMMA) phantom. The system absolute photon detection efficiency, measured via source irradiation, varies in the range [1, 4] x 10(-4) with energy variations in the prompt gamma (PG) energy range and source position shifts with respect to the center of the camera. With proton and carbon beams impinging on a PMMA cylindrical phantom, the number of detected PG coincidences related to various beam time structure has been studied. Finally, the accuracy of the camera in identifying the dose profile fall-off position has been estimated and two different event reconstruction methods have been compared for this purpose; one based on analytical calculation with a line-cone technique, the second relying on an iterative maximum likelihood expectation maximization algorithm. Both methods showed the possibility to reconstruct the beam depth-dose profile and to retrieve the dose fall-off with millimeter precision on a spot basis.
引用
收藏
页码：218 / 232
页数：15
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