Versatile synthesis of 3-arylindan-1-ones by palladium-catalyzed intramolecular reductive cyclization of bromochalcones

被引：19
|
作者：
Püschl, A
Rudbeck, HC
Faldt, A
Confante, A
Kehler, J
机构：
[1] H Lundbeck & Co AS, Med Chem Res, DK-2500 Copenhagen, Denmark
[2] H Lundbeck & Co AS, Proc Res, DK-2500 Copenhagen, Denmark
来源：
SYNTHESIS-STUTTGART | 2005年 / 02期
关键词：
3-arylindan-1-ones; palladium; reductive cyclization; chalcone; intramolecular;
D O I：
10.1055/s-2004-834929
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have developed a novel and versatile synthesis of racemic 3-arylindan-1-ones by palladium-catalyzed intramolecular reductive cyclization of bromochalcones. This method is especially attractive because it avoids strong acidic conditions and consequently a larger number of sensitive functional groups are accepted during synthesis compared with existing methods.
引用
收藏
页码：291 / 295
页数：5
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