Versatile synthesis of 3-arylindan-1-ones by palladium-catalyzed intramolecular reductive cyclization of bromochalcones

被引：19

作者：

Püschl, A

Rudbeck, HC

Faldt, A

Confante, A

Kehler, J

机构：

[1] H Lundbeck & Co AS, Med Chem Res, DK-2500 Copenhagen, Denmark

[2] H Lundbeck & Co AS, Proc Res, DK-2500 Copenhagen, Denmark

来源：

SYNTHESIS-STUTTGART | 2005年 / 02期

关键词：

3-arylindan-1-ones; palladium; reductive cyclization; chalcone; intramolecular;

D O I：

10.1055/s-2004-834929

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed a novel and versatile synthesis of racemic 3-arylindan-1-ones by palladium-catalyzed intramolecular reductive cyclization of bromochalcones. This method is especially attractive because it avoids strong acidic conditions and consequently a larger number of sensitive functional groups are accepted during synthesis compared with existing methods.

引用

页码：291 / 295

页数：5

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