Enantioselective Addition of Diethylzinc to Aromatic Aldehydes Using Chiral Oxazoline-Based Ligands

被引：1
|
作者：
Aydin, A. E. [1 ]
机构：
[1] Hatay Mustafa Kemal Univ, Arts & Sci Fac, Dept Chem, TR-31040 Antakya, Turkey
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 56卷 / 07期
关键词：
asymmetric catalysis; enantioselective synthesis; chiral oxazoline-based ligands; 1; 2-addition; ASYMMETRIC HENRY REACTIONS; BIS(OXAZOLINE) LIGANDS; DIFERROCENYL DICHALCOGENIDES; ORGANOZINC ADDITIONS; FACILE SYNTHESIS; AMINO-ALCOHOLS; COMPLEXES; CATALYSTS; REAGENTS; ALKYLATION;
D O I：
10.1134/S1070428020070271
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Chiral oxazoline ligands containing an aromatic ring were prepared from norephedrine and pyrrole-2-carbonitrile or 2-hydroxybenzoyl chloride. The synthesized ligands were used in the copper-catalyzed asymmetric addition of diethylzinc to aromatic aldehydes to provide optically active 1-arylpropan-1-ols with high conversion (92%) and enantioselectivity (up to 99%ee).
引用
收藏
页码：1304 / 1312
页数：9
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