CHIRAL PIPERAZINES AS CATALYSTS FOR THE ENANTIOSELECTIVE ADDITION OF DIETHYLZINC TO ALDEHYDES

被引：0

作者：

FUJI, K

TANAKA, K

MIYAMOTO, H

机构：

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1993年 / 41卷 / 09期

关键词：

CHIRAL PIPERAZINE; ASYMMETRIC ALKYLATION; CHIRAL CATALYST; DIETHYLZINC; ENANTIOSELECTIVE ADDITION;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Enantioselective ethylation of benzaldehyde with diethylzinc in the presence of a catalytic amount of chiral piperazine derivatives was investigated. The chiral piperazine works as an asymmetric catalyst in the alkylation, yielding 1-phenylpropanol with a moderate enantioselectivity. The influence of structural variation of the piperazine ring upon the asymmetric induction and the mechanism involved are discussed.

引用

页码：1557 / 1561

页数：5

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