CHIRAL PIPERAZINES AS CATALYSTS FOR THE ENANTIOSELECTIVE ADDITION OF DIETHYLZINC TO ALDEHYDES

被引：0
|
作者：
FUJI, K
TANAKA, K
MIYAMOTO, H
机构：
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1993年 / 41卷 / 09期
关键词：
CHIRAL PIPERAZINE; ASYMMETRIC ALKYLATION; CHIRAL CATALYST; DIETHYLZINC; ENANTIOSELECTIVE ADDITION;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Enantioselective ethylation of benzaldehyde with diethylzinc in the presence of a catalytic amount of chiral piperazine derivatives was investigated. The chiral piperazine works as an asymmetric catalyst in the alkylation, yielding 1-phenylpropanol with a moderate enantioselectivity. The influence of structural variation of the piperazine ring upon the asymmetric induction and the mechanism involved are discussed.
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页码：1557 / 1561
页数：5
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