Chiral pyrrolidine derivatives as catalysts for the enantioselective addition of diethylzinc to aldehydes

被引：0

作者：

Ikota, N

Inaba, H

机构：

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1996年 / 44卷 / 03期

关键词：

asymmetric addition; chiral hydroxylated pyrrolidine; D-ribonoiactone; chiral catalyst ligand; diethylzinc; optically active secondary;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A chiral hydroxylated pyrrolidine derivative (4) and an N-(2-mercaptoethyl)pyrrolidine derivative (1c) were synthesized from D-ribonolactone and were used as chiral catalyst ligands in the reaction of diethylzinc and aldehydes. High asymmetric induction of up to 95% ee was observed in the addition to aromatic aldehydes using the chiral hydroxylated pyrrolidine derivative 4.

引用

页码：587 / 589

页数：3

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