Synthesis of novel chiral tridentate aminophenol ligands for enantioselective addition of diethylzinc to aldehydes

被引：31
|
作者：
Yang, Xiao-Feng [1 ,2 ]
Hirose, Takuji [1 ]
Zhang, Guang-You [2 ]
机构：
[1] Saitama Univ, Grad Sch Sci & Engn, Sakura Ku, Saitama 3388570, Japan
[2] Univ Jinan, Dept Chem Engn, Jinan 250022, Shandong, Peoples R China
来源：
TETRAHEDRON-ASYMMETRY | 2008年 / 19卷 / 14期
关键词：
D O I：
10.1016/j.tetasy.2008.06.027
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Novel chiral tridentate aminophenol ligand (S)-3a was obtained by a Mannich-type reaction of cresol, paraformaldehyde, and (S)-1-(2-metboxyplienyl)-2-methylpropan-1-amine followed by a deprotection step. This tridentate aminophenol ligand shows high yield and enantioselectivity in the diethylzinc additions to a broad range of substrates, including alkyl, aryl, and alpha,beta-unsaturated aldehydes. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1670 / 1675
页数：6
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