Synthesis and application of chiral β-amino disulfides as ligands for the enantioselective addition of diethylzinc to aldehydes

被引：27
|
作者：
Braga, Antonio L. [1 ]
Galetto, Fabio Z. [1 ]
Rodrigues, Oscar E. D. [2 ]
Silveira, Claudio C. [1 ]
Paixao, Marcio W. [3 ]
机构：
[1] Univ Fed Santa Maria, Dept Quim, BR-97105900 Santa Maria, RS, Brazil
[2] Ctr Univ Franciscano, Santa Maria, RS, Brazil
[3] Univ Sao Paulo, Inst Quim, Sao Paulo, Brazil
来源：
CHIRALITY | 2008年 / 20卷 / 07期
关键词：
asymmetric catalysis; chiral ligands; thiols; sulfur; zinc;
D O I：
10.1002/chir.20554
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new class of chiral beta-amino disulfides was synthesized from readily available and inexpensive starting materials by a straightforward method and their abilities as ligands were examined in the enantioselective addition of diethylzinc to aldehydes. Enantiomeric excesses of up to 99% have been obtained using 0.5 mol % of the chiral catalysts.
引用
收藏
页码：839 / 845
页数：7
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