Copper-Catalyzed gem-Difluoroolefination of Diazo Compounds with TMSCF3 via C-F Bond Cleavage

被引：203
|
作者：
Hu, Mingyou [1 ]
He, Zhengbiao [1 ]
Gao, Bing [1 ]
Li, Lingchun [1 ]
Ni, Chuanfa [1 ]
Hu, Jinbo [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 46期
基金：
中国国家自然科学基金;
关键词：
CROSS-COUPLING REACTIONS; 1,1-DIFLUORO OLEFINS; H BOND; CARBONYL-COMPOUNDS; CONVENIENT METHOD; METAL CARBENE; TRIFLUOROMETHYLATION; FLUORINATION; ACTIVATION; CONVERSION;
D O I：
10.1021/ja409941r
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel Cu-catalyzed gem-difluoroolefination of diazo compounds is described. This transformation starts from readily available TMSCF3 and diazo compounds, via trifluoromethylation followed by C-F bond cleavage, to afford the desired 1,1-difluoroalkene products.
引用
收藏
页码：17302 / 17305
页数：4
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