Stereodivergent Palladium-Catalyzed C-F Bond Functionalization of gem-Difluoroalkenes

被引：0
|
作者：
Wang, Yanhui [1 ]
Tsui, Gavin Chit [1 ,2 ]
机构：
[1] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong 999077, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai Hong Kong Joint Lab Chem Synth, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2024年
关键词：
STEREOSELECTIVE-SYNTHESIS; ALPHA-FLUOROALKENYLATION; ACTIVATION; HYDRODEFLUORINATION; SECONDARY; TERTIARY; ALKYNES; ACIDS;
D O I：
10.1021/acs.orglett.4c02112
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We herein describe a stereodivergent C-F bond functionalization of gem-difluoroalkenes. Using trisubstituted beta,beta-difluoroacrylates, both E and Z monofluoroalkene products can be obtained with excellent diastereoselectivities. The design of two different reaction manifolds, i.e., Pd(II)- versus Pd(0)-catalyzed cross-coupling of boronic acids, is the key to stereocontrol.
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页数：5
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