Dammarane-type triterpene saponins from the roots of Panax notoginseng (Burk.) F. H. Chen and their neuroprotective effects

被引：5
|
作者：
Ning, Zhiheng [1 ,2 ]
He, Ziliang [2 ]
Yang, Guigui [2 ]
Wang, Yanting [2 ]
Zhang, Guolin [3 ]
Khan, Ashfaq-Ahmad [4 ]
Li, Fu [3 ]
Zhang, Ji [1 ,2 ]
Hu, Weicheng [5 ]
机构：
[1] Xinjiang Agr Univ, Coll Food Sci & Pharmacol, Urumqi 830052, Peoples R China
[2] Huaiyin Normal Univ, Sch Life Sci, Huaian 223300, Peoples R China
[3] Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Res Ctr, Chengdu 610041, Peoples R China
[4] Women Univ Azad Jammu & Kashmir Bagh, Bagh 12500, Pakistan
[5] Yangzhou Univ, Inst Translat Med, Sch Med, Yangzhou 225009, Peoples R China
来源：
FITOTERAPIA | 2023年 / 168卷
关键词：
Panax notoginseng; Triterpenene saponins; Neuroprotective effects; INJURY; CELLS;
D O I：
10.1016/j.fitote.2023.105541
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three undescribed dammarane-type triterpene saponins, 20(S)-sanchirhinoside A7-A9 (1-3), together with seventeen known ones, were isolated from the roots of Panax notoginseng (Burk.) F. H. Chen. The chemical structures of the new compounds were determined by HR-MS and NMR experiments along with chemical methods. To the best of our knowledge, compound 1 was the firstly reported fucose-containing triterpene saponin from plants in the genus of Panax. Moreover, the in vitro neuroprotective effects of the isolated com-pounds were evaluated. Compounds 11-12 displayed remarkable protective effects against PC12 cells injured by 6-hydroxydopamine.
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页数：5
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