Dammarane-type triterpene saponins from the roots of Panax notoginseng (Burk.) F. H. Chen and their neuroprotective effects

被引：5

作者：

Ning, Zhiheng ^{[1
,2
]}

He, Ziliang ^{[2
]}

Yang, Guigui ^{[2
]}

Wang, Yanting ^{[2
]}

Zhang, Guolin ^{[3
]}

Khan, Ashfaq-Ahmad ^{[4
]}

Li, Fu ^{[3
]}

Zhang, Ji ^{[1
,2
]}

Hu, Weicheng ^{[5
]}

机构：

[1] Xinjiang Agr Univ, Coll Food Sci & Pharmacol, Urumqi 830052, Peoples R China

[2] Huaiyin Normal Univ, Sch Life Sci, Huaian 223300, Peoples R China

[3] Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Res Ctr, Chengdu 610041, Peoples R China

[4] Women Univ Azad Jammu & Kashmir Bagh, Bagh 12500, Pakistan

[5] Yangzhou Univ, Inst Translat Med, Sch Med, Yangzhou 225009, Peoples R China

来源：

FITOTERAPIA | 2023年 / 168卷

关键词：

Panax notoginseng; Triterpenene saponins; Neuroprotective effects; INJURY; CELLS;

D O I：

10.1016/j.fitote.2023.105541

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three undescribed dammarane-type triterpene saponins, 20(S)-sanchirhinoside A7-A9 (1-3), together with seventeen known ones, were isolated from the roots of Panax notoginseng (Burk.) F. H. Chen. The chemical structures of the new compounds were determined by HR-MS and NMR experiments along with chemical methods. To the best of our knowledge, compound 1 was the firstly reported fucose-containing triterpene saponin from plants in the genus of Panax. Moreover, the in vitro neuroprotective effects of the isolated com-pounds were evaluated. Compounds 11-12 displayed remarkable protective effects against PC12 cells injured by 6-hydroxydopamine.

引用

页数：5

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