Dammarane-type triterpene saponins from the roots of Panax notoginseng (Burk.) F. H. Chen and their neuroprotective effects

被引：1

作者：

Ning, Zhiheng ^{[1
,2
]}

He, Ziliang ^{[2
]}

Yang, Guigui ^{[2
]}

Wang, Yanting ^{[2
]}

Zhang, Guolin ^{[3
]}

Khan, Ashfaq-Ahmad ^{[4
]}

Li, Fu ^{[3
]}

Zhang, Ji ^{[1
,2
]}

Hu, Weicheng ^{[5
]}

机构：

[1] Xinjiang Agr Univ, Coll Food Sci & Pharmacol, Urumqi 830052, Peoples R China

[2] Huaiyin Normal Univ, Sch Life Sci, Huaian 223300, Peoples R China

[3] Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Res Ctr, Chengdu 610041, Peoples R China

[4] Women Univ Azad Jammu & Kashmir Bagh, Bagh 12500, Pakistan

[5] Yangzhou Univ, Inst Translat Med, Sch Med, Yangzhou 225009, Peoples R China

来源：

FITOTERAPIA | 2023年 / 168卷

关键词：

Panax notoginseng; Triterpenene saponins; Neuroprotective effects; INJURY; CELLS;

D O I：

10.1016/j.fitote.2023.105541

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three undescribed dammarane-type triterpene saponins, 20(S)-sanchirhinoside A7-A9 (1-3), together with seventeen known ones, were isolated from the roots of Panax notoginseng (Burk.) F. H. Chen. The chemical structures of the new compounds were determined by HR-MS and NMR experiments along with chemical methods. To the best of our knowledge, compound 1 was the firstly reported fucose-containing triterpene saponin from plants in the genus of Panax. Moreover, the in vitro neuroprotective effects of the isolated com-pounds were evaluated. Compounds 11-12 displayed remarkable protective effects against PC12 cells injured by 6-hydroxydopamine.

引用

页数：5

共 50 条

[1] Bioactive Protopanaxatriol Type Saponins Isolated from the Roots of Panax Notoginseng (Burk.) F. H. Chen
Zhang, Yi
Han, Li-Feng
Sakah, Kaunda Joseph
Wu, Zhi-Zhen
Liu, Li-Li
Agyemang, Kojo
Gao, Xiu-Mei
Wang, Tao
[J]. MOLECULES, 2013, 18 (09) : 10352 - 10366
[2] Dammarane-type Triterpene Saponins from the Flowers of Panax notoginseng
Wang, Jing-Rong
Yamasaki, Yuko
Tanaka, Takashi
Kouno, Isao
Jiang, Zhi-Hong
[J]. MOLECULES, 2009, 14 (06) : 2087 - 2094
[3] New Dammarane-Type Saponins from the Roots of Panax notoginseng
Qiu, Li
Jiao, Yang
Huang, Gui-Kun
Xie, Ji-Zhao
Miao, Jian-Hua
Yao, Xin-Sheng
[J]. HELVETICA CHIMICA ACTA, 2014, 97 (01) : 102 - 111
[4] Bioactive saponins and glycosides .8. Notoginseng .1. New dammarane-type triterpene oligoglycosides, notoginsenosides-A, -B, -C, and -D, from the dried root of Panax notoginseng (Burk) F. H. Chen
Yoshikawa, M
Murakami, T
Ueno, T
Yashiro, K
Hirokawa, N
Murakami, N
Yamahara, J
Matsuda, H
Saijoh, R
Tanaka, O
[J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 1997, 45 (06) : 1039 - 1045
[5] Effect of pulsed vacuum drying on drying kinetics and quality of roots of Panax notoginseng (Burk.) F. H. Chen (Araliaceae)
Jiang, Dalong
Xiao, Hongwei
Zielinska, Magdalena
Zhu, Guangfei
Bai, Tianyu
Zheng, Zhian
[J]. DRYING TECHNOLOGY, 2021, 39 (16) : 2234 - 2251
[6] Separation of dammarane-saponins from notoginseng, root of Panax notoginseng (Burk.) F.H.!Chen, by HSCCC coupled with evaporative light scattering detector
Cao, XL
Tian, Y
Zhang, TY
Liu, QH
Jia, LJ
Ito, Y
[J]. JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2003, 26 (9-10) : 1579 - 1591
[7] Six new dammarane-type triterpene saponins from the processed leaves of Panax notoginseng
Zhang, Mingyan
Sun, Xiaojuan
Ren, Rui
Su, Lihua
Xu, Min
Zheng, Lixiong
Li, Haizhou
[J]. PHYTOCHEMISTRY LETTERS, 2022, 49 : 145 - 151
[8] Dammarane-type triterpene saponins from Panax japonicus
Zou, K
Zhu, S
Tohda, C
Cai, SQ
Komatsu, K
[J]. JOURNAL OF NATURAL PRODUCTS, 2002, 65 (03): : 346 - 351
[9] New dammarane-type triterpenoid saponins from Panax notoginseng saponins
Li, Qian
Yuan, Mingrui
Li, Xiaohui
Li, Jinyu
Xu, Ming
Wei, Di
Wu, Desong
Wan, Jinfu
Mei, Shuangxi
Cui, Tao
Wang, Jingkun
Zhu, Zhaoyun
[J]. JOURNAL OF GINSENG RESEARCH, 2020, 44 (05) : 673 - 679
[10] Dammarane-type saponins from steamed leaves of Panax Notoginseng
Liu Q.
Lv J.-J.
Xu M.
Wang D.
Zhu H.-T.
Yang C.-R.
Zhang Y.-J.
[J]. Natural Products and Bioprospecting, 2011, 1 (3) : 124 - 128

← 1 2 3 4 5 →