Six new dammarane-type triterpene saponins from the processed leaves of Panax notoginseng

Six new dammarane-type triterpenoid saponins, notoginsenosides SFt5-SFt10 (1-6) were isolated from the processed leaves of Panax notoginseng (Burk.) F.H.Chen (Araliaceae), together with eight known notoginsenosides (7-14), fourteen known ginsenosides (15-28), two known vinaginsenosides (29-30), and one known gypenoside (31). Their structures were established by detailed spectroscopic analysis (NMR, UV, IR, HRESI-MS) and acidic hydrolysis. Four compounds notoginsenoside SFt1 (7), ginsenosides Rg5 (17), C-Mc (23) and 20(R)-Rg3 (25) have significant protective effects against L-glutamate-induced SH-SY5Y nerve injury (10 mu M).