Specifics of Experimental Modeling 8-OH-DPAT-Induced Perseverative Behavior in Mice

被引：1

作者：

Kudryashov, N. V. ^{[1
]}

Volkova, A. V. ^{[1
]}

Shimshirt, A. A. ^{[1
]}

Naplekova, P. L. ^{[1
]}

Voronina, T. A. ^{[1
]}

Seredenin, S. B. ^{[1
]}

机构：

[1] VV Zakusov Res Inst Pharmacol, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2023年 / 175卷 / 1期

关键词：

perseverative behavior; obsessive-compulsive disorder; 8-OH-DPAT; 5-HT1A receptors; MEMORY; MAZE;

D O I：

10.1007/s10517-023-05807-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of 5-HT1A receptor agonist 8-OH-DPAT (intraperitoneal injection in doses of 1, 2, and 4 mg/kg) on spontaneous alternation behavior of mice in Y-maze was studied without and with habituation procedure and food reward. In the first case, 8-OH-DPAT administration led to a decrease in spontaneous alternation and locomotor activity in mice. At the same time, 8-OH-DPAT treatment after habituation and food deprivation increased repeated choices of goal arms without affecting locomotor activity, which was consistent with perseverative behavior. 8-OH-DPAT-induced decrease in spontaneous alternation behavior in Y-maze in mice with habituation and food reward is the most suitable procedure for experimental modeling of the perseverative behavior and studying the anticompulsive activity of new substances.

引用

页码：41 / 44

页数：4

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