Specifics of Experimental Modeling 8-OH-DPAT-Induced Perseverative Behavior in Mice

被引：1
|
作者：
Kudryashov, N. V. [1 ]
Volkova, A. V. [1 ]
Shimshirt, A. A. [1 ]
Naplekova, P. L. [1 ]
Voronina, T. A. [1 ]
Seredenin, S. B. [1 ]
机构：
[1] VV Zakusov Res Inst Pharmacol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2023年 / 175卷 / 1期
关键词：
perseverative behavior; obsessive-compulsive disorder; 8-OH-DPAT; 5-HT1A receptors; MEMORY; MAZE;
D O I：
10.1007/s10517-023-05807-0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effect of 5-HT1A receptor agonist 8-OH-DPAT (intraperitoneal injection in doses of 1, 2, and 4 mg/kg) on spontaneous alternation behavior of mice in Y-maze was studied without and with habituation procedure and food reward. In the first case, 8-OH-DPAT administration led to a decrease in spontaneous alternation and locomotor activity in mice. At the same time, 8-OH-DPAT treatment after habituation and food deprivation increased repeated choices of goal arms without affecting locomotor activity, which was consistent with perseverative behavior. 8-OH-DPAT-induced decrease in spontaneous alternation behavior in Y-maze in mice with habituation and food reward is the most suitable procedure for experimental modeling of the perseverative behavior and studying the anticompulsive activity of new substances.
引用
收藏
页码：41 / 44
页数：4
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