Specifics of Experimental Modeling 8-OH-DPAT-Induced Perseverative Behavior in Mice

被引：1
|
作者：
Kudryashov, N. V. [1 ]
Volkova, A. V. [1 ]
Shimshirt, A. A. [1 ]
Naplekova, P. L. [1 ]
Voronina, T. A. [1 ]
Seredenin, S. B. [1 ]
机构：
[1] VV Zakusov Res Inst Pharmacol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2023年 / 175卷 / 1期
关键词：
perseverative behavior; obsessive-compulsive disorder; 8-OH-DPAT; 5-HT1A receptors; MEMORY; MAZE;
D O I：
10.1007/s10517-023-05807-0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effect of 5-HT1A receptor agonist 8-OH-DPAT (intraperitoneal injection in doses of 1, 2, and 4 mg/kg) on spontaneous alternation behavior of mice in Y-maze was studied without and with habituation procedure and food reward. In the first case, 8-OH-DPAT administration led to a decrease in spontaneous alternation and locomotor activity in mice. At the same time, 8-OH-DPAT treatment after habituation and food deprivation increased repeated choices of goal arms without affecting locomotor activity, which was consistent with perseverative behavior. 8-OH-DPAT-induced decrease in spontaneous alternation behavior in Y-maze in mice with habituation and food reward is the most suitable procedure for experimental modeling of the perseverative behavior and studying the anticompulsive activity of new substances.
引用
收藏
页码：41 / 44
页数：4
相关论文
共 50 条
  • [31] Baseline and 8-OH-DPAT-induced release of acetylcholine in the hippocampus of aged rats with different levels of cognitive dysfunction
    Lazaris, A
    Bertrand, F
    Lazarus, C
    Galani, R
    Stemmelin, J
    Poirier, R
    Kelche, C
    Cassel, JC
    BRAIN RESEARCH, 2003, 967 (1-2) : 181 - 190
  • [32] Eating high fat chow increases the sensitivity of rats to 8-OH-DPAT-induced lower lip retraction
    Li, Jun-Xu
    Ju, Shutian
    Baladi, Michelle G.
    Koek, Wouter
    France, Charles P.
    BEHAVIOURAL PHARMACOLOGY, 2011, 22 (08): : 751 - 757
  • [33] Effects of adrenalectomy on 8-OH-DPAT induced hypothermia in mice
    R. H. McAllister-Williams
    M. S. Man
    A. H. Young
    Psychopharmacology, 1999, 142 : 73 - 77
  • [34] Effects of adrenalectomy on 8-OH-DPAT induced hypothermia in mice
    McAllister-Williams, RH
    Man, MS
    Young, AH
    PSYCHOPHARMACOLOGY, 1999, 142 (01) : 73 - 77
  • [35] 8-OH-DPAT-INDUCED CORTICOSTERONE SECRETION AS AN INVIVO MODEL OF 5-HT1A RECEPTOR FUNCTION
    RIVET, JM
    MILLAN, MJ
    COLPAERT, FC
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 183 (03) : 684 - 685
  • [36] (-)-PENBUTOLOL ANTAGONIZES 8-OH-DPAT-INDUCED INHIBITION OF RAT 5-HYDROXYTRYPTAMINERGIC DORSAL RAPHE NEURONS
    VANDERMAELEN, CP
    BRASELTON, JP
    BRITISH JOURNAL OF PHARMACOLOGY, 1992, 107 : P2 - P2
  • [37] THE LACK OF EFFECT OF REPEATED TREATMENT WITH ANTIDEPRESSANT DRUGS ON THE 8-OH-DPAT-INDUCED INCREASE IN THE SERUM CORTICOSTERONE CONCENTRATION
    PRZEGALINSKI, E
    WARCHOLKANIA, A
    BUDZISZEWSKA, B
    POLISH JOURNAL OF PHARMACOLOGY AND PHARMACY, 1989, 41 (01): : 63 - 68
  • [38] Effects of Thalamic Reticular Nucleus Electrical Stimulation in Rats in a T-maze Perseverative Behavior Model Induced by 8-OH-DPAT
    Andrade, Pablo
    Carrillo-Ruiz, Jose D.
    Ramirez, Ylian
    Jimenez, Fiacro
    NEUROMODULATION, 2010, 13 (01): : 2 - 8
  • [39] Effects of Thalamic Reticular Nucleus Electrical Stimulation in Rats in a T-Maze Perseverative Behavior Model Induced by 8-OH-DPAT
    Jimenez, Fiacro
    Andrade, Pablo
    Ramirez, Ylian
    Carrillo, Jose D.
    BIOLOGICAL PSYCHIATRY, 2009, 65 (08) : 119S - 120S
  • [40] Ginsenoside Re attenuates 8-OH-DPAT-induced serotonergic behaviors in mice via interactive modulation between PKCδ gene and Nrf2
    Shin, Eun-Joo
    Jeong, Ji Hoon
    Bao-Trong Nguyen
    Sharma, Naveen
    Cuong Ngoc Kim Tran
    Nah, Seung-Yeol
    Lee, Yi
    Byun, Jae Kyung
    Ko, Sung Kwon
    Kim, Hyoung-Chun
    DRUG AND CHEMICAL TOXICOLOGY, 2023, 46 (02) : 281 - 296
12345