TJS']JS-010, a new prescription of oriental medicine, enhances 8-OH-DPAT-induced effects in rats

被引：0
|
作者：
Kagaya, A [1 ]
Tanra, AJ [1 ]
Shinno, H [1 ]
Kugaya, A [1 ]
Muraoka, M [1 ]
Oyamada, T [1 ]
Uchitomi, Y [1 ]
Yamawaki, S [1 ]
机构：
[1] HIROSHIMA UNIV,SCH MED,DEPT PSYCHIAT & NEUROSCI,MINAMI KU,HIROSHIMA 734,JAPAN
来源：
JOURNAL OF NEURAL TRANSMISSION | 1996年 / 103卷 / 1-2期
关键词：
Kampo; hypothermia; flat body posture; 5-HT-1A receptors; anxiety;
D O I：
10.1007/BF01292617
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We evaluated the effect of TJS-010, a new prescription of oriental medicine, on hypothermia and flat body posture in rats, induced by activation of serotonin (5-HT)-1A receptors by (+/-)-8-hydroxy-2-(di-N-propylamino)-tetralin (8-OH-DPAT). Hypothermia was induced by 8-OH-DPAT in a dose and time-dependent manner. The hypothermia induced by 0.1 mg/kg 8-OH-DPAT was enhanced by 500 and 750 mg/kg of TJS-010. At the concentration of 0.1 mg/kg, 8-OH-DPAT also produced flat body posture in rats. and 750 mg/kg TJS-010 increased the flat body posture. These results suggest that TJS-010 facilitates the 5-HT-1A receptors in the central nervous system.
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收藏
页码：69 / 75
页数：7
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