TJS']JS-010, a new prescription of oriental medicine, enhances 8-OH-DPAT-induced effects in rats

被引：0

作者：

Kagaya, A ^{[1
]}

Tanra, AJ ^{[1
]}

Shinno, H ^{[1
]}

Kugaya, A ^{[1
]}

Muraoka, M ^{[1
]}

Oyamada, T ^{[1
]}

Uchitomi, Y ^{[1
]}

Yamawaki, S ^{[1
]}

机构：

[1] HIROSHIMA UNIV,SCH MED,DEPT PSYCHIAT & NEUROSCI,MINAMI KU,HIROSHIMA 734,JAPAN

来源：

JOURNAL OF NEURAL TRANSMISSION | 1996年 / 103卷 / 1-2期

关键词：

Kampo; hypothermia; flat body posture; 5-HT-1A receptors; anxiety;

D O I：

10.1007/BF01292617

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We evaluated the effect of TJS-010, a new prescription of oriental medicine, on hypothermia and flat body posture in rats, induced by activation of serotonin (5-HT)-1A receptors by (+/-)-8-hydroxy-2-(di-N-propylamino)-tetralin (8-OH-DPAT). Hypothermia was induced by 8-OH-DPAT in a dose and time-dependent manner. The hypothermia induced by 0.1 mg/kg 8-OH-DPAT was enhanced by 500 and 750 mg/kg of TJS-010. At the concentration of 0.1 mg/kg, 8-OH-DPAT also produced flat body posture in rats. and 750 mg/kg TJS-010 increased the flat body posture. These results suggest that TJS-010 facilitates the 5-HT-1A receptors in the central nervous system.

引用

页码：69 / 75

页数：7

共 43 条

[41] Effects of adrenalectomy on hyperphagia induced by the 5-HT1A receptor agonist 8-OH-DPAT and 2-deoxy-D-glucose in rats
Yamada, Y
Sugimoto, Y
Yoshikawa, T
NEUROREPORT, 1998, 9 (08) : 1831 - 1833
[42] The effects of 8-OH-DPAT and (±)-pindolol on isolation-induced ultrasonic vocalizations in 3-, 10-, and 14-day-old rats
Joyce, MP
Carden, SE
DEVELOPMENTAL PSYCHOBIOLOGY, 1999, 34 (02) : 109 - 117
[43] CHRONIC LITHIUM TREATMENT ENHANCES THE POSTSYNAPTIC 5-HT(1A) RECEPTOR-MEDIATED 5-HT BEHAVIORAL SYNDROME INDUCED BY 8-OH-DPAT IN RATS VIA CATECHOLAMINERGIC SYSTEMS
UCHITOMI, Y
YAMAWAKI, S
PSYCHOPHARMACOLOGY, 1993, 112 (01) : 74 - 79

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