TJS']JS-010, a new prescription of oriental medicine, enhances 8-OH-DPAT-induced effects in rats

被引：0

作者：

Kagaya, A ^{[1
]}

Tanra, AJ ^{[1
]}

Shinno, H ^{[1
]}

Kugaya, A ^{[1
]}

Muraoka, M ^{[1
]}

Oyamada, T ^{[1
]}

Uchitomi, Y ^{[1
]}

Yamawaki, S ^{[1
]}

机构：

[1] HIROSHIMA UNIV,SCH MED,DEPT PSYCHIAT & NEUROSCI,MINAMI KU,HIROSHIMA 734,JAPAN

来源：

JOURNAL OF NEURAL TRANSMISSION | 1996年 / 103卷 / 1-2期

关键词：

Kampo; hypothermia; flat body posture; 5-HT-1A receptors; anxiety;

D O I：

10.1007/BF01292617

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We evaluated the effect of TJS-010, a new prescription of oriental medicine, on hypothermia and flat body posture in rats, induced by activation of serotonin (5-HT)-1A receptors by (+/-)-8-hydroxy-2-(di-N-propylamino)-tetralin (8-OH-DPAT). Hypothermia was induced by 8-OH-DPAT in a dose and time-dependent manner. The hypothermia induced by 0.1 mg/kg 8-OH-DPAT was enhanced by 500 and 750 mg/kg of TJS-010. At the concentration of 0.1 mg/kg, 8-OH-DPAT also produced flat body posture in rats. and 750 mg/kg TJS-010 increased the flat body posture. These results suggest that TJS-010 facilitates the 5-HT-1A receptors in the central nervous system.

引用

页码：69 / 75

页数：7

共 43 条

[31] THE EFFECTS OF WAY-100635, A POTENT AND SELECTIVE 5-HT1A RECEPTOR ANTAGONIST, ON FEEDING AND 8-OH-DPAT-INDUCED FEEDING IN THE RAT
HARTLEY, JE
FORSTER, EA
FLETCHER, A
BRITISH JOURNAL OF PHARMACOLOGY, 1994, 112 : U151 - U151
[32] Blockade of dopamine d1 but not d2 receptors attenuates the effect of clomipramine on the 8-OH-DPAT-induced deficit in spontaneous alternation behavior in rats
Piotr Gruca
Magda Lason-Tyburkiewicz
Mariusz Papp
Pharmacological Reports, 2009, 61 : 355 - 355
[33] 8-OH-DPAT-induced effects on prepulse inhibition:: Pre- vs. post-synaptic 5-HT1A receptor activation
Gogos, A
Kusljic, S
van den Buuse, M
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2005, 81 (03) : 664 - 672
[34] EFFECTS OF CHLORDIAZEPOXIDE, 8-OH-DPAT AND ONDANSETRON ON RADIATION-INDUCED DECREASES IN FOOD-INTAKE IN RATS
WINSAUER, PJ
VERREES, JF
OHALLORAN, KP
BIXLER, MA
MELE, PC
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1994, 270 (01): : 142 - 149
[35] Onset of the effects of the 5-HT1A antagonist, WAY-100635, alone, and in combination with paroxetine, on olfactory bulbectomy and 8-OH-DPAT-induced changes in the rat
Cryan, JF
McGrath, C
Leonard, BE
Norman, TR
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1999, 63 (02) : 333 - 338
[36] THE NOVEL 5-HT1A RECEPTOR ANTAGONIST (S)-UH-301 ANTAGONIZES 8-OH-DPAT-INDUCED EFFECTS ON MALE AS WELL AS FEMALE RAT COPULATORY-BEHAVIOR
JOHANSSON, CE
MEYERSON, BJ
HACKSELL, U
EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 202 (01) : 81 - 87
[37] Effects of Thalamic Reticular Nucleus Electrical Stimulation in Rats in a T-Maze Perseverative Behavior Model Induced by 8-OH-DPAT
Jimenez, Fiacro
Andrade, Pablo
Ramirez, Ylian
Carrillo, Jose D.
BIOLOGICAL PSYCHIATRY, 2009, 65 (08) : 119S - 120S
[38] Effects of Thalamic Reticular Nucleus Electrical Stimulation in Rats in a T-maze Perseverative Behavior Model Induced by 8-OH-DPAT
Andrade, Pablo
Carrillo-Ruiz, Jose D.
Ramirez, Ylian
Jimenez, Fiacro
NEUROMODULATION, 2010, 13 (01): : 2 - 8
[39] Effects of Thalamic Reticular Nucleus Electrical Stimulation in Rats in a T-maze Perseverative Behavior Model Induced by 8-OH-DPAT Comment
Foreman, Robert D.
NEUROMODULATION, 2010, 13 (01): : 8 - 9
[40] Interaction between 5-HT1A and 5-HT1B receptors:: effects of 8-OH-DPAT-induced hypothermia in 5-HT1B receptor knockout mice
Gardier, AM
Gruwez, B
Trillat, AC
Jacquot, C
Hen, R
Bourin, M
EUROPEAN JOURNAL OF PHARMACOLOGY, 2001, 421 (03) : 171 - 175

← 1 2 3 4 5 →