Synthesis and Biological Activity of Esters Based on Cycloalkenedicarboxylic Acids

被引：1

作者：

Firstova, A. A. ^{[1
]}

Kofanov, E. R. ^{[1
]}

Kovaleva, M. I. ^{[2
]}

机构：

[1] Yaroslavl State Tech Univ, Yaroslavl 150023, Russia

[2] Yaroslavl Demidov State Univ, Yaroslavl 150003, Russia

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2023年 / 49卷 / 01期

关键词：

N-substituted imides of carboxylic acids; esters; cycloalkenyl fragments; L-amino acid; cytotoxicity; biological activity; mutagenicity; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; BARLEY HORDEUM-VULGARE; CUSHINGS-SYNDROME; INHIBITORS; RESISTANCE; DISCOVERY; AMIDES;

D O I：

10.1134/S1068162023010089

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previously undeclared esters based on N-substituted imides of cycloaliphatic carboxylic acids were synthesized with high yields, and effective methods for their preparation described. Toxicological studies of the obtained compounds were performed with the use of various test objects (Chlorella vulgaris, Allium cepa, and Drosophila melanogaster). The tested compounds were shown to be inactive against D. melanogaster, to increase the frequency of mutations for C. vulgaris, and to have an ability to induce chromosomal rearrangements in A. cepa. The synthesized compounds could be used for a design of antitumor drugs.

引用

页码：65 / 75

页数：11

共 50 条

[21] Polyurethanes based on dihydroxamic acids. Synthesis, chemical characterization, and biological activity
Buruiana, T
Spridon, D
Buruiana, EC
Hefco, V
Uglea, CV
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 1999, 10 (11) : 1159 - 1170
[22] Amino acids esters of acyclovir-synthesis and antiviral activity
Stankova, I. G.
Shichkov, S.
JOURNAL OF PEPTIDE SCIENCE, 2010, 16 : 185 - 185
[23] Synthesis and optical activity of difluoro(organylsulfinyl) acetic acids and their esters
Matsnev, AV
Kondratenko, NV
Yagupolskii, YL
Yagupolskii, LM
TETRAHEDRON LETTERS, 2002, 43 (16) : 2949 - 2952
[24] Synthesis and Antiradical Activity of Isoquercitrin Esters with Aromatic Acids and Their Homologues
Hermankova-Vavrikova, Eva
Krenkova, Alena
Petraskova, Lucie
Chambers, Christopher Steven
Zapal, Jakub
Kuzma, Marek
Valentova, Katerina
Kren, Vladimir
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (05)
[25] SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF INDOLE CARBOXYLIC-ACIDS AND ESTERS
ANDREANI, A
RAMBALDI, M
LOCATELLI, A
CONTI, M
MALANDRINO, S
ACTA PHARMACEUTICA NORDICA, 1991, 3 (01): : 5 - 8
[26] AMINOACETYLENIC ESTERS OF BENZOIC-ACIDS - SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY
DZHURAYEV, AD
MAKHSUMOV, AG
ZAKIROV, UB
NIKBAYEV, AT
KARIMKULOV, K
KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1990, 24 (08): : 30 - 31
[27] Synthesis and biological activity of glycosyl N-solanesylaminocarboxylic esters
Zhao, J
Liu, L
Song, JY
Wang, CJ
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2004, 24 (12) : 1601 - 1605
[28] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF GEM-DICHLORCYCLOPROPYL ESTERS
SHOSTAKOVSKY, SM
MOCHALOV, VN
LARIONOV, GM
KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1985, 19 (11): : 1330 - 1335
[29] CYTOKININS - SYNTHESIS AND BIOLOGICAL ACTIVITY OF ZEATIN ESTERS AND RELATED COMPOUNDS
SCHMITZ, RY
SKOOG, F
HECHT, SM
LEONARD, NJ
PHYTOCHEMISTRY, 1971, 10 (02) : 275 - &
[30] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF ORGANO-SILICON ESTERS
LAPKIN, II
PIDEMSKY, EL
POVARNITSINA, TN
GOLENEVA, AF
MARDANOVA, LG
DVINSKIKH, VV
KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1983, 17 (07): : 817 - 822

← 1 2 3 4 5 →