Synthesis and Biological Activity of Esters Based on Cycloalkenedicarboxylic Acids

被引：1

作者：

Firstova, A. A. ^{[1
]}

Kofanov, E. R. ^{[1
]}

Kovaleva, M. I. ^{[2
]}

机构：

[1] Yaroslavl State Tech Univ, Yaroslavl 150023, Russia

[2] Yaroslavl Demidov State Univ, Yaroslavl 150003, Russia

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2023年 / 49卷 / 01期

关键词：

N-substituted imides of carboxylic acids; esters; cycloalkenyl fragments; L-amino acid; cytotoxicity; biological activity; mutagenicity; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; BARLEY HORDEUM-VULGARE; CUSHINGS-SYNDROME; INHIBITORS; RESISTANCE; DISCOVERY; AMIDES;

D O I：

10.1134/S1068162023010089

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previously undeclared esters based on N-substituted imides of cycloaliphatic carboxylic acids were synthesized with high yields, and effective methods for their preparation described. Toxicological studies of the obtained compounds were performed with the use of various test objects (Chlorella vulgaris, Allium cepa, and Drosophila melanogaster). The tested compounds were shown to be inactive against D. melanogaster, to increase the frequency of mutations for C. vulgaris, and to have an ability to induce chromosomal rearrangements in A. cepa. The synthesized compounds could be used for a design of antitumor drugs.

引用

页码：65 / 75

页数：11

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