Synthesis and Biological Activity of Esters Based on Cycloalkenedicarboxylic Acids

Previously undeclared esters based on N-substituted imides of cycloaliphatic carboxylic acids were synthesized with high yields, and effective methods for their preparation described. Toxicological studies of the obtained compounds were performed with the use of various test objects (Chlorella vulgaris, Allium cepa, and Drosophila melanogaster). The tested compounds were shown to be inactive against D. melanogaster, to increase the frequency of mutations for C. vulgaris, and to have an ability to induce chromosomal rearrangements in A. cepa. The synthesized compounds could be used for a design of antitumor drugs.