Two new sesquiterpene glycosides from the stems of Dendrobium henanense and their anti-inflammatory activity

被引：0

作者：

Wu, Si-Yu ^{[1
,2
]}

Jie, Hui-Yang ^{[1
]}

Wu, De-Ling ^{[1
,3
,4
]}

Qin, Shi-Hui ^{[1
]}

Tang, Xu ^{[1
]}

Wang, Ren-Zhong ^{[1
,4
]}

Xu, Feng-Qing ^{[1
,3
,4
]}

机构：

[1] Anhui Univ Chinese Med, Sch Pharm, Hefei, Peoples R China

[2] Taihe Cty Hosp Tradit Chinese Med, Taihe, Peoples R China

[3] Anhui Prov Key Lab New Mfg Technol Tradit Chinese, Hefei, Peoples R China

[4] Anhui Prov Key Lab Res & Dev Chinese Med, Hefei, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2024年

关键词：

Dendrobium henanense; terpenoids; NMR; anti-inflammatory; PICROTOXANE; COPACAMPHANE;

D O I：

10.1080/14786419.2024.2301739

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new sesquiterpene glycosides, 8 alpha,12,15 beta-trihydroxycopacamphan-15-O-beta-D-glucopyranoside (1) and dendrobiumane C-11-O-beta-D-glucopyranoside (2), along with three known terpenoids (3-5) were isolated from the aerial stems of Dendrobium henanense. Their structures were elucidated based on NMR-spectroscopic and HR-MS analyses. All compounds could reduce the levels of NO, TNF-alpha and IL-1 beta in LPS-induced RAW264.7 cells with IC50 values ranging from 10.37 to 34.55 mu M.

引用

页数：6

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