Two new flavanone glycosides from Scutellaria galericulata with anti-inflammatory activities

Two new flavanone glycosides, named scugalerosides A and B (1-2), were isolated from the whole plant of Scutellaria galericulata. Their chemical structures including absolute configurations were established on the basis of detailed physical data analyses. In vitro, two new compounds showed anti-inflammatory activities, with the inhibition rates of release of beta-glucuronidase from polymorphonuclear leukocytes of rats being 43.7% and 45.1% at concentrations of 10 mu M.