Two new sesquiterpene glycosides from the stems of Dendrobium henanense and their anti-inflammatory activity

被引：0
|
作者：
Wu, Si-Yu [1 ,2 ]
Jie, Hui-Yang [1 ]
Wu, De-Ling [1 ,3 ,4 ]
Qin, Shi-Hui [1 ]
Tang, Xu [1 ]
Wang, Ren-Zhong [1 ,4 ]
Xu, Feng-Qing [1 ,3 ,4 ]
机构：
[1] Anhui Univ Chinese Med, Sch Pharm, Hefei, Peoples R China
[2] Taihe Cty Hosp Tradit Chinese Med, Taihe, Peoples R China
[3] Anhui Prov Key Lab New Mfg Technol Tradit Chinese, Hefei, Peoples R China
[4] Anhui Prov Key Lab Res & Dev Chinese Med, Hefei, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2024年
关键词：
Dendrobium henanense; terpenoids; NMR; anti-inflammatory; PICROTOXANE; COPACAMPHANE;
D O I：
10.1080/14786419.2024.2301739
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Two new sesquiterpene glycosides, 8 alpha,12,15 beta-trihydroxycopacamphan-15-O-beta-D-glucopyranoside (1) and dendrobiumane C-11-O-beta-D-glucopyranoside (2), along with three known terpenoids (3-5) were isolated from the aerial stems of Dendrobium henanense. Their structures were elucidated based on NMR-spectroscopic and HR-MS analyses. All compounds could reduce the levels of NO, TNF-alpha and IL-1 beta in LPS-induced RAW264.7 cells with IC50 values ranging from 10.37 to 34.55 mu M.
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页数：6
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