An expanded role for mTORC1 in autophagy

被引：7

作者：

Kim, Young-Mi ^{[1
]}

Park, Ji-Man ^{[1
]}

Grunwald, Douglas ^{[1
]}

Kim, Do-Hyung ^{[1
,2
]}

机构：

[1] Univ Minnesota, Dept Biochem, Mol Biol & Biophys, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2016年 / 3卷 / 01期

基金：

美国国家卫生研究院;

关键词：

mTOR; mTORC1; autophagy; UVRAG; RUBICON; endosome; lysosome;

D O I：

10.1080/23723556.2015.1010958

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mechanistic target of rapamycin complex 1 (mTORC1) negatively regulates autophagy at early stages by phosphorylating Unc51-like kinase 1 (ULK1). Our recent study expanded the roles of mTORC1 in autophagy by identifying ultraviolet radiation resistance-associated gene product (UVRAG) as a substrate of mTORC1. This finding has provided new insight into the roles of mTORC1 in cellular membrane processes and cancer.

引用

页数：3

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