A division of labor in mTORC1 signaling and autophagy

被引：16
|
作者：
Martens, Sascha [1 ,2 ]
机构：
[1] Univ Vienna, Vienna BioCtr, Dept Biochem, Cell Biol, Dr Bohr Gasse 9-3, A-1030 Vienna, Austria
[2] Univ Vienna, Vienna BioCtr, Max F Perutz Labs, Dr Bohr Gasse 9-3, A-1030 Vienna, Austria
来源：
SCIENCE SIGNALING | 2018年 / 11卷 / 559期
关键词：
D O I：
10.1126/scisignal.aav3530
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In human cells, the p62 protein acts as an adaptor in various signaling pathways as well as a receptor for selective autophagy. In this issue of Science Signaling, Sanchez-Garrido et al. show that proteolytic cleavage of p62 by caspase-8 determines whether p62 functions as an mTORC1 signaling adaptor or autophagy receptor.
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Elevated MTORC1 signaling and impaired autophagy
    Ramos, Fresnida J.
    Kaeberlein, Matt
    Kennedy, Brian K.
    [J]. AUTOPHAGY, 2013, 9 (01) : 108 - 109
  • [2] Defective Autophagy and mTORC1 Signaling in Myotubularin Null Mice
    Fetalvero, Kristina M.
    Yu, Yenyen
    Goetschkes, Margaret
    Liang, Guiqing
    Valdez, Reginald A.
    Gould, Ty
    Triantafellow, Ellen
    Bergling, Sebastian
    Loureiro, Joseph
    Eash, John
    Lin, Victor
    Porter, Jeffrey A.
    Finan, Peter M.
    Walsh, Kenneth
    Yang, Yi
    Mao, Xiaohong
    Murphy, Leon O.
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2013, 33 (01) : 98 - 110
  • [3] TFEB-driven endocytosis coordinates MTORC1 signaling and autophagy
    Nnah, Israel C.
    Wang, Biao
    Saqcena, Chaitali
    Weber, Gregory F.
    Bonder, Edward M.
    Bagley, Dustin
    De Cegli, Rossella
    Napolitano, Gennaro
    Medina, Diego L.
    Ballabio, Andrea
    Dobrowolski, Radek
    [J]. AUTOPHAGY, 2019, 15 (01) : 151 - 164
  • [4] Gαq activation modulates autophagy by promoting mTORC1 signaling
    Cabezudo, Sofia
    Sanz-Flores, Maria
    Caballero, Alvaro
    Tasset, Inmaculada
    Rebollo, Elena
    Diaz, Antonio
    Aragay, Anna M.
    Cuervo, Ana Maria
    Mayor Jr, Federico
    Ribas, Catalina
    [J]. NATURE COMMUNICATIONS, 2021, 12 (01)
  • [5] Gαq activation modulates autophagy by promoting mTORC1 signaling
    Sofía Cabezudo
    Maria Sanz-Flores
    Alvaro Caballero
    Inmaculada Tasset
    Elena Rebollo
    Antonio Diaz
    Anna M. Aragay
    Ana María Cuervo
    Federico Mayor
    Catalina Ribas
    [J]. Nature Communications, 12
  • [6] The impact of DAPK1 and mTORC1 signaling association on autophagy in cancer
    Parvaneh Movahhed
    Mohammadreza Saberiyan
    Amir Safi
    Zahra Arshadi
    Faranak Kazerouni
    Hossein Teimori
    [J]. Molecular Biology Reports, 2022, 49 : 4959 - 4964
  • [7] The impact of DAPK1 and mTORC1 signaling association on autophagy in cancer
    Movahhed, Parvaneh
    Saberiyan, Mohammadreza
    Safi, Amir
    Arshadi, Zahra
    Kazerouni, Faranak
    Teimori, Hossein
    [J]. MOLECULAR BIOLOGY REPORTS, 2022, 49 (06) : 4959 - 4964
  • [8] An expanded role for mTORC1 in autophagy
    Kim, Young-Mi
    Park, Ji-Man
    Grunwald, Douglas
    Kim, Do-Hyung
    [J]. MOLECULAR & CELLULAR ONCOLOGY, 2016, 3 (01):
  • [9] mTORC1 as the main gateway to autophagy
    Rabanal-Ruiz, Yoana
    Otten, Elsje G.
    Korolchuk, Viktor I.
    [J]. SIGNALLING MECHANISMS IN AUTOPHAGY, 2017, 61 (06): : 565 - 584
  • [10] Cytoskeletal vimentin regulates cell size and autophagy through mTORC1 signaling
    Mohanasundaram, Ponnuswamy
    Coelho-Rato, Leila S.
    Modi, Mayank Kumar
    Urbanska, Marta
    Lautenschlaeger, Franziska
    Cheng, Fang
    Eriksson, John E.
    [J]. PLOS BIOLOGY, 2022, 20 (09)
12345