Dysregulation of mTORC1/autophagy axis in senescence

被引：7
|
作者：
Carroll, Bernadette [1 ]
Korolchuk, Viktor I. [1 ]
机构：
[1] Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
来源：
AGING-US | 2017年 / 9卷 / 08期
基金：
英国生物技术与生命科学研究理事会;
关键词：
senescence; mTORC1; autophagy;
D O I：
10.18632/aging.101277
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
引用
收藏
页码：1851 / 1852
页数：2
相关论文
共 50 条
  • [1] An expanded role for mTORC1 in autophagy
    Kim, Young-Mi
    Park, Ji-Man
    Grunwald, Douglas
    Kim, Do-Hyung
    MOLECULAR & CELLULAR ONCOLOGY, 2016, 3 (01):
  • [2] mTORC1 as the main gateway to autophagy
    Rabanal-Ruiz, Yoana
    Otten, Elsje G.
    Korolchuk, Viktor I.
    SIGNALLING MECHANISMS IN AUTOPHAGY, 2017, 61 (06): : 565 - 584
  • [3] Pathological Consequences of Hepatic mTORC1 Dysregulation
    Cho, Chun-Seok
    Kowalsky, Allison Ho
    Lee, Jun Hee
    GENES, 2020, 11 (08) : 1 - 9
  • [4] Deregulation of mTORC1/autophagy axis during senescence leads to death of Ras-transformed cells upon MEK/ERK inhibition
    Kochetkova, E. Y.
    Blinova, G., I
    Bystrova, O. A.
    Martynova, M. G.
    Pospelov, V. A.
    Pospelova, T., V
    CELL DEATH DISCOVERY, 2019, 5
  • [5] A division of labor in mTORC1 signaling and autophagy
    Martens, Sascha
    SCIENCE SIGNALING, 2018, 11 (559)
  • [6] Elevated MTORC1 signaling and impaired autophagy
    Ramos, Fresnida J.
    Kaeberlein, Matt
    Kennedy, Brian K.
    AUTOPHAGY, 2013, 9 (01) : 108 - 109
  • [7] The Emerging Roles of mTORC1 in Macromanaging Autophagy
    Dossou, Akpedje S.
    Basu, Alakananda
    CANCERS, 2019, 11 (10)
  • [8] Dysregulation of mTORC1 Signaling in Childhood Solid Tumors
    Houghton, P. J.
    Cam, H.
    KLINISCHE PADIATRIE, 2011, 223 (01): : 45 - 45
  • [9] mTORC1 hyperactivation in skeletal muscle produces early-onset myopathy associated with autophagy dysregulation
    Kim, Myungjin
    Brooks, Susan
    Lee, Jun Hee
    FASEB JOURNAL, 2021, 35
  • [10] Too Sweet for Autophagy: Hexokinase Inhibition of mTORC1 Activates Autophagy
    Kundu, Mondira
    MOLECULAR CELL, 2014, 53 (04) : 517 - 518
12345