The Role of mTORC1 Pathway and Autophagy in Resistance to Platinum-Based Chemotherapeutics

被引：5

作者：

Pan, Zhenrui ^{[1
]}

Zhang, Hanxiao ^{[1
]}

Dokudovskaya, Svetlana ^{[1
]}

机构：

[1] Univ Paris Saclay, Inst Gustave Roussy, CNRS, UMR9018, F-94805 Villejuif, France

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 13期

关键词：

mTORC1; pathway; autophagy; cisplatin; anticancer drug resistance; OVARIAN-CANCER CELLS; AMINO-ACID; RAG GTPASES; CISPLATIN SENSITIVITY; IN-VITRO; PHASE-I; EVEROLIMUS; GROWTH; MECHANISM; CIS-DIAMMINEDICHLOROPLATINUM(II);

D O I：

10.3390/ijms241310651

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cisplatin (cis-diamminedichloroplatinum I) is a platinum-based drug, the mainstay of anticancer treatment for numerous solid tumors. Since its approval by the FDA in 1978, the drug has continued to be used for the treatment of half of epithelial cancers. However, resistance to cisplatin represents a major obstacle during anticancer therapy. Here, we review recent findings on how the mTORC1 pathway and autophagy can influence cisplatin sensitivity and resistance and how these data can be applicable for the development of new therapeutic strategies.

引用

页数：16

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