TISSUE DISTRIBUTION OF HUMAN MONOAMINE OXIDASE-A AND OXIDASE-B MESSENGER-RNA

被引:147
|
作者
GRIMSBY, J
LAN, NC
NEVE, R
CHEN, K
SHIH, JC
机构
[1] UNIV SO CALIF,SCH PHARM,DIV BIOL SCI,1985 ZONAL AVE,LOS ANGELES,CA 90033
[2] UNIV CALIF IRVINE,DEPT PSYCHOBIOL,IRVINE,CA 92717
关键词
Human brain monoamine oxidase A and B; Human fetal monoamine oxidase A and B; Monoamine oxidase A and B mRNA; Placenta monoamine oxidase A; Small intestine monoamine oxidase A and B; Tissue distribution;
D O I
10.1111/j.1471-4159.1990.tb03121.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Abstract: Monoamine oxidase (MAO) A and B play important roles in the metabolism of biogenic amines. Northern analysis using 32P‐labeled subfragments of human liver MAO A and B cDNA clones detected a 5‐ and a 3‐kb transcript, respectively, in most human tissues examined. However, fetal heart and thymus express minute amounts of MAO A transcript, whereas fetal brain, muscle, thymus, spleen, meninges, and placenta express minute amounts of MAO B transcript. Small intestine and placenta express, in addition to the MAO A 5‐kb transcript, a 2‐kb transcript, which may arise from an alternative polyadenylation site. MAO A and B transcripts are expressed in similar regions of adult human brain. The highest concentrations of these transcripts were located in frontal cortex and locus coeruleus. This study demonstrates the tissue‐specific distribution of the MAO genes and will provide insight into the physiological functions of MAO A and B. Copyright © 1990, Wiley Blackwell. All rights reserved
引用
收藏
页码:1166 / 1169
页数:4
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