Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity

被引：27
|
作者：
Bartl, Jasmin [1 ]
Mueller, Thomas [2 ]
Gruenblatt, Edna [1 ,3 ,4 ]
Gerlach, Manfred
Riederer, Peter
机构：
[1] Univ Zurich, Hosp Child & Adolescent Psychiat, CH-8057 Zurich, Switzerland
[2] St Joseph Hosp Berlin Weissensee, Dept Neurol, Berlin, Germany
[3] Univ Zurich, Neurosci Ctr Zurich, Zurich, Switzerland
[4] Swiss Fed Inst Technol, Zurich, Switzerland
来源：
JOURNAL OF NEURAL TRANSMISSION | 2014年 / 121卷 / 04期
关键词：
Parkinson's disease; MAO-A; MAO-B inhibitors; Selegiline; Rasagiline; MAO-B; PHARMACOKINETICS; SELEGILINE; DOPAMINE;
D O I：
10.1007/s00702-013-1120-z
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Patients with Parkinson's disease receive selective irreversible monoamine oxidase (MAO)-B inhibitors, but their effects on MAO-A activity are not known during long-term application. We determined MAO-A inhibition in plasma samples from patients with MAO-B inhibitor intake or without MAO-B inhibitor treatment and from healthy controls. We detected a 70 % reduction of MAO-A activity in patients with MAO-B inhibitor therapy in comparison to the other groups. Our results suggest that treatment with MAO-B inhibitor may also influence MAO-A activity in vivo, when administered daily.
引用
收藏
页码：379 / 383
页数：5
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