Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity

被引：0

作者：

Jasmin Bartl

Thomas Müller

Edna Grünblatt

Manfred Gerlach

Peter Riederer

机构：

[1] University of Zurich,Hospital of Child and Adolescent Psychiatry

[2] St. Joseph Hospital Berlin-Weissensee,Department of Neurology

[3] University of Zurich and ETH Zurich,Neuroscience Center Zurich

[4] University Hospital of Wuerzburg,Department of Psychiatry, Psychosomatics and Psychotherapy

[5] University of Wuerzburg,Department of Child and Adolescents Psychiatry, Psychosomatics and Psychotherapy

[6] Institute Cognitive Brain Sciences,undefined

[7] NCGG,undefined

[8] University Hospital of Wuerzburg,undefined

[9] University of Wuerzburg,undefined

来源：

Journal of Neural Transmission | 2014年 / 121卷

关键词：

Parkinson’s disease; MAO-A; MAO-B inhibitors; Selegiline; Rasagiline;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Patients with Parkinson’s disease receive selective irreversible monoamine oxidase (MAO)-B inhibitors, but their effects on MAO-A activity are not known during long-term application. We determined MAO-A inhibition in plasma samples from patients with MAO-B inhibitor intake or without MAO-B inhibitor treatment and from healthy controls. We detected a 70 % reduction of MAO-A activity in patients with MAO-B inhibitor therapy in comparison to the other groups. Our results suggest that treatment with MAO-B inhibitor may also influence MAO-A activity in vivo, when administered daily.

引用

页码：379 / 383

页数：4

共 50 条

[1] Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity
Bartl, Jasmin
Mueller, Thomas
Gruenblatt, Edna
Gerlach, Manfred
Riederer, Peter
[J]. JOURNAL OF NEURAL TRANSMISSION, 2014, 121 (04) : 379 - 383
[2] THE KINETIC MECHANISMS OF MONOAMINE OXIDASE-A AND OXIDASE-B
RAMSAY, RR
SINGER, TP
[J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 1991, 19 (01) : 219 - 223
[3] SELECTIVE INHIBITORS OF MONOAMINE OXIDASE-A AND OXIDASE-B
WILLIAMS, CH
[J]. BIOCHEMICAL PHARMACOLOGY, 1984, 33 (02) : 334 - 337
[4] THE ACTIVITY OF MONOAMINE OXIDASE-A AND OXIDASE-B IN BRAINS FROM CHRONIC-ALCOHOLICS
ORELAND, L
WIBERG, A
WINBLAD, B
FOWLER, CJ
GOTTFRIES, CG
KIIANMAA, K
[J]. JOURNAL OF NEURAL TRANSMISSION, 1983, 56 (01) : 73 - 83
[5] MONOAMINE OXIDASE-A AND MONOAMINE OXIDASE-B ACTIVITIES ARE CATALYZED BY DIFFERENT PROTEINS
SMITH, D
FILIPOWICZ, C
MCCAULEY, R
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 831 (01) : 1 - 7
[6] AN EVALUATION OF PHOSPHOLIPIDS AS REGULATORS OF MONOAMINE OXIDASE-A AND MONOAMINE OXIDASE-B ACTIVITIES
NAVARROWELCH, C
MCCAULEY, RB
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1982, 257 (22) : 13645 - 13649
[7] DEVELOPMENT OF BENZYLAMINE OXIDASE AND MONOAMINE OXIDASE-A AND OXIDASE-B IN MAN
LEWINSOHN, R
GLOVER, V
SANDLER, M
[J]. BIOCHEMICAL PHARMACOLOGY, 1980, 29 (09) : 1221 - 1230
[8] AN EXAMINATION OF THE RELIABILITY OF THE RADIOCHEMICAL ASSAY FOR MONOAMINE OXIDASE-A AND OXIDASE-B
KRUEGER, MJ
SINGER, TP
[J]. ANALYTICAL BIOCHEMISTRY, 1993, 214 (01) : 116 - 123
[9] DISTINCT MONOAMINE OXIDASE-A AND OXIDASE-B POPULATIONS IN PRIMATE BRAIN
WESTLUND, KN
DENNEY, RM
KOCHERSPERGER, LM
ROSE, RM
ABELL, CW
[J]. SCIENCE, 1985, 230 (4722) : 181 - 183
[10] IMMUNOLOGICAL UNIQUENESS OF MONOAMINE OXIDASE-A AND OXIDASE-B MONOCLONAL-ANTIBODIES SPECIFIC FOR MONOAMINE-OXIDASE
KOCHERSPERGER, ALM
WAGUESPACK, A
DENNEY, RM
WEYLER, W
SALACH, JI
[J]. JOURNAL OF CELL BIOLOGY, 1984, 99 (04): : A20 - A20

← 1 2 3 4 5 →