NEW HETEROCYCLIC-DERIVATIVES OF BENZIMIDAZOLE WITH GERMICIDAL ACTIVITY .11. EXPERIMENTAL VALIDATION OF QSAR PREDICTION ON ANTIBACTERIAL AND ANTIMYCOTIC ACTIVITY OF BENZIMIDAZOLE DERIVATIVES

被引：0

作者：

PEDINI, M

DEMEO, G

RICCI, A

BASTIANINI, L

机构：

[1] UNIV PERUGIA,FAC MED & CHIRURG,IST BIOCHIM & CHIM MED,I-06123 PERUGIA,ITALY

[2] UNIV PERUGIA,FAC MED & CHIRURG,DIPARTIMENTO MED SPERIMENTALE & SCI BIOCHIM,SEZ MICROBIOL,I-06124 PERUGIA,ITALY

来源：

FARMACO | 1994年 / 49卷 / 10期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In continuation of previous studies, Authors describe the synthesis of three new derivatives of 2-(5'-nitro-2'-furyl) benzimidazole, having hydroxy, methoxy or amino group at position 5. The new compounds, synthesized as suggested by a previous chemometric study, were tested in vitro against 5 Gram + and 4 Gram- strains and the mycete C. albicans. Two derivatives (R=OH, NH2) showed a good degree of antibacterial activity, especially the 5-hydroxy derivative, but they were practically inactive against the mycete; these results are in agreement with the prediction of chemometric study.

引用

页码：671 / 674

页数：4

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