NEW HETEROCYCLIC-DERIVATIVES OF BENZIMIDAZOLE WITH GERMICIDAL ACTIVITY .11. EXPERIMENTAL VALIDATION OF QSAR PREDICTION ON ANTIBACTERIAL AND ANTIMYCOTIC ACTIVITY OF BENZIMIDAZOLE DERIVATIVES

被引：0
|
作者：
PEDINI, M
DEMEO, G
RICCI, A
BASTIANINI, L
机构：
[1] UNIV PERUGIA,FAC MED & CHIRURG,IST BIOCHIM & CHIM MED,I-06123 PERUGIA,ITALY
[2] UNIV PERUGIA,FAC MED & CHIRURG,DIPARTIMENTO MED SPERIMENTALE & SCI BIOCHIM,SEZ MICROBIOL,I-06124 PERUGIA,ITALY
来源：
FARMACO | 1994年 / 49卷 / 10期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In continuation of previous studies, Authors describe the synthesis of three new derivatives of 2-(5'-nitro-2'-furyl) benzimidazole, having hydroxy, methoxy or amino group at position 5. The new compounds, synthesized as suggested by a previous chemometric study, were tested in vitro against 5 Gram + and 4 Gram- strains and the mycete C. albicans. Two derivatives (R=OH, NH2) showed a good degree of antibacterial activity, especially the 5-hydroxy derivative, but they were practically inactive against the mycete; these results are in agreement with the prediction of chemometric study.
引用
收藏
页码：671 / 674
页数：4
相关论文
共 50 条
  • [41] Synthesis, pharmacological activity evaluation and molecular modeling of new polynuclear heterocyclic compounds containing benzimidazole derivatives
    Bassyouni, Fatma A.
    Saleh, Tamer S.
    ElHefnawi, Mahmoud M.
    Abd El-Moez, Sherein I.
    El-Senousy, Waled M.
    Abdel-Rehim, Mohamed E.
    ARCHIVES OF PHARMACAL RESEARCH, 2012, 35 (12) : 2063 - 2075
  • [42] SYNTHESIS AND TUBERCULOSTATIC ACTIVITY OF SOME NEW 2-BENZIMIDAZOLE DERIVATIVES
    VERESHCHAGINA, NN
    MELKOZEROVA, GS
    FROLOVA, NN
    BEDRIN, AV
    POSTOVSKII, IY
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1973, 7 (06): : 18 - 20
  • [43] Synthesis of some new benzimidazole carbamate derivatives for evaluation of antifungal activity
    Kus, C
    Altanlar, N
    TURKISH JOURNAL OF CHEMISTRY, 2003, 27 (01): : 35 - 39
  • [44] Synthesis and Anticandidal Activity Evaluation of New Benzimidazole-Thiazole Derivatives
    Kaplancikli, Zafer Asim
    Levent, Serkan
    Osmaniye, Derya
    Saglik, Begum Nurpelin
    Cevik, Ulviye Acar
    Cavusoglu, Betul Kaya
    Ozkay, Yusuf
    Ilgin, Sinem
    MOLECULES, 2017, 22 (12):
  • [45] Synthesis, physicochemical properties and antimicrobial activity of some new benzimidazole derivatives
    Ansari, K. F.
    Lal, C.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (10) : 4028 - 4033
  • [46] Microwave assisted synthesis and cytotoxic activity evaluations of new benzimidazole derivatives
    Hue Thi Buu Bui
    Quy Thi Kim Ha
    Oh, Won Keun
    Duy Duc Vo
    Yen Nguyen Tram Chau
    Cuc Thi Kim Tu
    Em Canh Pham
    Phuong Thao Tran
    Loan Thi Tran
    Hieu Van Mai
    TETRAHEDRON LETTERS, 2016, 57 (08) : 887 - 891
  • [47] Synthesis, antiprotozoal and antibacterial activity of nitro- and halogeno-substituted benzimidazole derivatives
    Kazimierczuk, Z
    Upcroft, JA
    Upcroft, P
    Górska, A
    Starosciak, B
    Laudy, A
    ACTA BIOCHIMICA POLONICA, 2002, 49 (01) : 185 - 195
  • [48] SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF N-ARYLQUINOXALIN-2-AMINES BEARING BENZIMIDAZOLE DERIVATIVES
    Brahmeshwari, G.
    Bhaskar, P.
    Kumaraswamy, G.
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2015, 6 (02): : 752 - 756
  • [49] Synthesis and characterization of N-substituted benzimidazole derivatives and study of their antibacterial and antifungal activity
    Ravichandran, Y. Dominic
    Kishor, Rachna
    Hariharasubramanian, A.
    Priya, K. Mohana
    Khora, Samanta S.
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2015, 92 (06) : 915 - 917
  • [50] Microwave-Assisted Synthesis of Some New Benzimidazole Derivatives with their Antimicrobial Activity
    Mentese, Emre
    Yilmaz, Fatih
    Beris, Fatih Saban
    Bekircan, Olcay
    Kahveci, Bahittin
    CURRENT MICROWAVE CHEMISTRY, 2015, 2 (01) : 32 - 39
12345