Design, synthesis and antibacterial activity of novel actinonin derivatives containing benzimidazole heterocycles

被引：29

作者：

Zhang, Datong ^{[1
]}

Wang, Zongheng ^{[2
]}

Xu, Weiren ^{[3
]}

Sun, Fanggang ^{[1
]}

Tang, Lida ^{[3
]}

Wang, Jianwu ^{[1
]}

机构：

[1] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China

[2] Shandong Univ, Sch Life Sci, Jinan 250100, Shandong, Peoples R China

[3] Tianjin Inst Pharmaceut Res, Tianjin 300193, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 05期

关键词：

Actinonin derivatives; Benzimidazole; Synthesis; Antibacterial activity; MATRIX-METALLOPROTEINASE INHIBITORS; HYDROXAMIC ACIDS; PEPTIDE DEFORMYLASE; ESTERS;

D O I：

10.1016/j.ejmech.2008.05.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel actinonin derivatives containing a benzimidazole heterocycle linked as amide isostere have been designed and synthesized. The structures of all the synthesized compounds were confirmed by analytical and spectroscopic methods. All the compounds were evaluated in vitro against Staphylococcus aureus, Klebsiella pneumoniae, and Sarcina lutea. Among them, compound la with unsubstituted benzimidazole ring exhibited potent antibacterial activities. (C) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：2202 / 2210

页数：9

共 50 条

[1] Design, synthesis, and antibacterial activity of novel myricetin derivatives containing sulfonate
Shijun Su
Qing Zhou
Xuemei Tang
Feng Peng
Tingting Liu
Liwei Liu
Chengwei Xie
Ming He
Wei Xue
Monatshefte für Chemie - Chemical Monthly, 2021, 152 : 345 - 356
[2] Design, synthesis, and antibacterial activity of novel myricetin derivatives containing sulfonate
Su, Shijun
Zhou, Qing
Tang, Xuemei
Peng, Feng
Liu, Tingting
Liu, Liwei
Xie, Chengwei
He, Ming
Xue, Wei
MONATSHEFTE FUR CHEMIE, 2021, 152 (03): : 345 - 356
[3] Design, synthesis, and antibacterial activity of novel amide derivatives containing a sulfone moiety
Zou, Yue
Liu, Xing
Zhu, Zongnan
Zhang, Chao
Zhang, Yong
Zhao, Yuanzheng
Zhu, Xiang
Chen, Jixiang
MOLECULAR DIVERSITY, 2025,
[4] Design, synthesis, and antibacterial activity of novel thiochromanone derivatives containing an acylhydrazone moiety
Chi, Jiyan
Yu, Lu
Li, Pei
Xiao, Lingling
Tang, Zhangfei
Li, Jie
Tan, Shuming
Wang, Xiang
Chen, Meihang
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2022, 197 (01) : 13 - 17
[5] Synthesis and Anticancer Activity of Novel Actinonin Derivatives as HsPDF Inhibitors
Hu, Liu
Cai, Xing
Dong, Suzhen
Zhen, Yongjia
Hu, Jidi
Wang, Shenjun
Jiang, Jingwen
Huang, Jiawu
Han, Yuqiao
Qian, Yu
Yuan, Yanqiu
Hu, Wenhao
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 63 (13) : 6959 - 6978
[6] Design, Synthesis, Antibacterial Activity, and Mechanisms of Novel Benzofuran Derivatives Containing Disulfide Moieties
Li, Jianzhuan
Liu, Qiu
Li, Sha
Zeng, Lu
Yao, Jiahui
Li, Hongde
Shen, Zhongjie
Lu, Funeng
Wu, Zengxue
Song, Baoan
Song, Runjiang
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2024, 72 (18) : 10195 - 10205
[7] Design, synthesis and antibacterial activity of novel andrographolide derivatives
Wang, Zhongli
Yu, Pei
Zhang, Gaoxiao
Xu, Lipeng
Wang, Dingyuan
Wang, Liang
Zeng, Xiangping
Wang, Yuqiang
BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (12) : 4269 - 4274
[8] Design, Synthesis and Antibacterial Activity of Novel Pleuromutilin Derivatives
Liu, Huixian
Cui, Ge
Ma, Donglai
Zhang, Yue
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2020, 126 : 133 - 133
[9] Design, synthesis, and antibacterial activity of quinazolinone derivatives containing amides
Zhang, Wenjuan
Zhu, Yunying
Zhang, Miaohe
Mou, Honglan
Wu, Rong
Tang, Shouying
Zhou, Han
Luo, Jianlin
Wei, Xian
Feng, Shuang
Bai, Song
PHYTOCHEMISTRY LETTERS, 2023, 56 : 72 - 77
[10] Design, synthesis and antibacterial activity of quinazolinone derivatives containing glycosides
Bai, Song
Feng, Shuang
Zhang, Wenjuan
Mou, Honglan
Tang, Shouying
Zhou, Han
Luo, Jianlin
Wei, Xian
Zhu, Yunying
Wu, Rong
Zhang, Miaohe
MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 2024, 768 (05) : 72 - 88

← 1 2 3 4 5 →