SYNTHESIS OF POTENTIAL METABOLITES OF ETHYL (E)-4-[2-(3,4-DIHYDRO-4,4-DIMETHYL-2H-1-BENZOPYRAN-6-YL)-1-PROPENYL]BENZOATE

被引：3
|
作者：
SUNTHANKAR, PS
BERLIN, KD
NELSON, EC
THORNE, RL
GENO, PW
ARCHER, JC
ROLF, LL
BARTELS, KE
机构：
[1] OKLAHOMA STATE UNIV,DEPT CHEM,STILLWATER,OK 74078
[2] OKLAHOMA STATE UNIV,DEPT NUTR SCI,STILLWATER,OK 74078
[3] OKLAHOMA STATE UNIV,DEPT BIOCHEM,STILLWATER,OK 74078
[4] OKLAHOMA STATE UNIV,VET MED TEACHING HOSP,STILLWATER,OK 74078
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 1993年 / 82卷 / 05期
关键词：
D O I：
10.1002/jps.2600820522
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Potential metabolites of ethyl (E)-4-[2-(3.4-dihydro-4,4-dimethyl-2H-1-benzopyran-6-yl)-1-propenyl]benzoate were synthesized. The new compounds include ethyl 3-[3,4-dihydro-4,4-dimethyl-2H-1-benzopyran-6-yl]crotonate, 3-[3,4-dihydro-4,4-dimethyl-2H-1-benzopyran-6-yl]crotonic acid, 3,4-dihydro-4,4-dimethyl-2H-1-benzopyran-6-carboxylic acid, 4-[3,4-dihydro-4,4-dimethyl-2H-1-benzopyran-6-yl]DELTA2-butenolide, ethyl (E)-4-[3,4-dihydro-4,4-dimethyl-2H-1-benzopyran-6-yl)-3-hydroxy-1-propenyl]benzoate, ethyl (E)-4-[2-(3,4-dihydro-4,4-dimethyl-2H-1-benzopyran-6-yl)-2-propenal]benzoate, and ethyl (E)-4-12-(3,4-dihydro-4,4-dimethyl-2H-1-benzopyran-6-yl)-2-propenoic acid]benzoate. Stereospecific oxidizing reagents and/or conditions were developed for these sensitive systems and include the use of SeO2, Clorox bleach, activated MnO2, and NaClO2 in the presence of resorcinol as a chlorine scavenger.
引用
收藏
页码：543 / 545
页数：3
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