SYNTHESIS OF POTENTIAL METABOLITES OF ETHYL (E)-4-[2-(3,4-DIHYDRO-4,4-DIMETHYL-2H-1-BENZOPYRAN-6-YL)-1-PROPENYL]BENZOATE

被引：3

作者：

SUNTHANKAR, PS

BERLIN, KD

NELSON, EC

THORNE, RL

GENO, PW

ARCHER, JC

ROLF, LL

BARTELS, KE

机构：

[1] OKLAHOMA STATE UNIV,DEPT CHEM,STILLWATER,OK 74078

[2] OKLAHOMA STATE UNIV,DEPT NUTR SCI,STILLWATER,OK 74078

[3] OKLAHOMA STATE UNIV,DEPT BIOCHEM,STILLWATER,OK 74078

[4] OKLAHOMA STATE UNIV,VET MED TEACHING HOSP,STILLWATER,OK 74078

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1993年 / 82卷 / 05期

关键词：

D O I：

10.1002/jps.2600820522

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Potential metabolites of ethyl (E)-4-[2-(3.4-dihydro-4,4-dimethyl-2H-1-benzopyran-6-yl)-1-propenyl]benzoate were synthesized. The new compounds include ethyl 3-[3,4-dihydro-4,4-dimethyl-2H-1-benzopyran-6-yl]crotonate, 3-[3,4-dihydro-4,4-dimethyl-2H-1-benzopyran-6-yl]crotonic acid, 3,4-dihydro-4,4-dimethyl-2H-1-benzopyran-6-carboxylic acid, 4-[3,4-dihydro-4,4-dimethyl-2H-1-benzopyran-6-yl]DELTA2-butenolide, ethyl (E)-4-[3,4-dihydro-4,4-dimethyl-2H-1-benzopyran-6-yl)-3-hydroxy-1-propenyl]benzoate, ethyl (E)-4-[2-(3,4-dihydro-4,4-dimethyl-2H-1-benzopyran-6-yl)-2-propenal]benzoate, and ethyl (E)-4-12-(3,4-dihydro-4,4-dimethyl-2H-1-benzopyran-6-yl)-2-propenoic acid]benzoate. Stereospecific oxidizing reagents and/or conditions were developed for these sensitive systems and include the use of SeO2, Clorox bleach, activated MnO2, and NaClO2 in the presence of resorcinol as a chlorine scavenger.

引用

页码：543 / 545

页数：3

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