IMPROVED BRAIN DELIVERY OF ANTIVIRAL AGENTS THROUGH THE USE OF REDOX TARGETING

被引：7

作者：

BREWSTER, ME ^{[1
]}

BODOR, N ^{[1
]}

机构：

[1] UNIV FLORIDA, COLL PHARM, J HILLIS MILLER HLTH CTR, CTR DRUG DESIGN & DELIVERY, GAINESVILLE, FL 32610 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1994年 / 14卷 / 2-3期

基金：

美国国家卫生研究院;

关键词：

ANTIVIRAL; BLOOD-BRAIN BARRIER; BRAIN-TARGETED DELIVERY; AZIDOTHYMIDINE (ZIDOVUDINE); ACYCLOVIR; GANCICLOVIR; TRIFLUOROTHYMIDINE; RIBAVIRIN;

D O I：

10.1016/0169-409X(94)90038-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The inability to effectively deliver antiviral agents to the brain and central nervous system can be overcome via drug latentiation and, specifically, via a redox chemical delivery system. This approach has been successfully applied to a variety of agents, examples of which are summarized in this review. These include azidothymidine, azidouridine, dideoxydidehydrothymidine, acyclovir, trifluorothymidine, gancyclovir and ribavirin.

引用

页码：177 / 197

页数：21

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