IMPROVED BRAIN DELIVERY OF ANTIVIRAL AGENTS THROUGH THE USE OF REDOX TARGETING

被引：7
|
作者：
BREWSTER, ME [1 ]
BODOR, N [1 ]
机构：
[1] UNIV FLORIDA, COLL PHARM, J HILLIS MILLER HLTH CTR, CTR DRUG DESIGN & DELIVERY, GAINESVILLE, FL 32610 USA
来源：
ADVANCED DRUG DELIVERY REVIEWS | 1994年 / 14卷 / 2-3期
基金：
美国国家卫生研究院;
关键词：
ANTIVIRAL; BLOOD-BRAIN BARRIER; BRAIN-TARGETED DELIVERY; AZIDOTHYMIDINE (ZIDOVUDINE); ACYCLOVIR; GANCICLOVIR; TRIFLUOROTHYMIDINE; RIBAVIRIN;
D O I：
10.1016/0169-409X(94)90038-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The inability to effectively deliver antiviral agents to the brain and central nervous system can be overcome via drug latentiation and, specifically, via a redox chemical delivery system. This approach has been successfully applied to a variety of agents, examples of which are summarized in this review. These include azidothymidine, azidouridine, dideoxydidehydrothymidine, acyclovir, trifluorothymidine, gancyclovir and ribavirin.
引用
收藏
页码：177 / 197
页数：21
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