SYNTHESIS OF CEPHALOSPORINS HAVING A HETEROCYCLIC GROUP AT THE C-3 POSITION

被引：0
|
作者：
JUNG, MH [1 ]
CHO, KW [1 ]
KIM, WJ [1 ]
SHIN, JS [1 ]
PARK, CS [1 ]
机构：
[1] YUNGJIN PHARM CO LTD,KYUNGGI-DO 456860,SOUTH KOREA
来源：
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 1993年 / 14卷 / 01期
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
3-(3-Bromotetrahydrofuran-2-yl)-3-cephem 7 was obtained from 3-(2-hydroxyethyl)vinyl-3-cephem 6 by the cyclization reaction using N-bromosuccinimide. Compound 5 was prepared by Wittig reaction, namely a coupling of cephem-derived triphenylphosphonium salt 3 with aldehyde component 4 in the presence of base.
引用
收藏
页码：32 / 34
页数：3
相关论文
共 50 条
  • [31] Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position
    Zhou, Feng
    Liu, Yun-Lin
    Zhou, Jian
    ADVANCED SYNTHESIS & CATALYSIS, 2010, 352 (09) : 1381 - 1407
  • [32] CEPHALOSPORINS HAVING A HETEROCYCLIC CATECHOL IN THE C3 SIDE-CHAIN .2. IMPROVEMENT OF PHARMACOKINETIC PROFILE
    IIMURA, S
    IMAE, K
    HASEGAWA, T
    OKITA, T
    TAMAOKA, M
    MURATA, S
    KAMACHI, H
    KAMEI, H
    JOURNAL OF ANTIBIOTICS, 1993, 46 (05): : 850 - 857
  • [33] Synthesis and activities of bactobolin derivatives based on the alteration of the functionality at C-3 position
    Adachi, H
    Usui, T
    Nishimura, Y
    Kondo, S
    Ishizuka, M
    Takeuchi, T
    JOURNAL OF ANTIBIOTICS, 1998, 51 (02): : 184 - 188
  • [34] SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF CEPHALOSPORINS HAVING A CATECHOL IN THE C3 SIDE-CHAIN
    OKITA, T
    IMAE, K
    HASEGAWA, T
    IMURA, S
    MASUYOSHI, S
    KAMACHI, H
    KAMEI, H
    JOURNAL OF ANTIBIOTICS, 1993, 46 (05): : 833 - 839
  • [35] Cephalosporins with the (E)-thiovinyl linker with pyrimidine at C-3 position exhibiting potent activities against gram-positive strains
    Kim, GT
    Jang, YT
    Ryu, EJ
    Koo, KD
    Lee, CS
    Youn, H
    Cho, YR
    Joo, HY
    JOURNAL OF ANTIBIOTICS, 2004, 57 (07): : 473 - 476
  • [36] Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships
    Yokoo, Katsuki
    Yamawaki, Kenji
    Yoshida, Yutaka
    Yonezawa, Shuji
    Yamano, Yoshinori
    Tsuji, Masakatsu
    Hori, Toshihiko
    Nakamura, Rio
    Ishikura, Koji
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 124 : 698 - 712
  • [37] STUDIES ON NEW CATECHOL CONTAINING CEPHALOSPORINS .2. SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF CEPHALOSPORINS HAVING A CATECHOL MOIETY AT THE C-7 POSITION
    CHOI, KI
    CHA, JH
    PAE, AN
    CHO, YS
    KANG, HY
    KOH, HY
    CHANG, MH
    JOURNAL OF ANTIBIOTICS, 1995, 48 (11): : 1375 - 1377
  • [38] Synthesis and structure-activity relationship of C-3 benzoyloxymethyl cephalosporins exhibiting anti-MRSA activities
    Kim, OK
    Ueda, Y
    Mansuri, MM
    Russell, JW
    Bidwell, VW
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (14) : 1945 - 1950
  • [39] Advances in Research on Pharmacological Activities and Synthesis of Oleanolic Acid Derivatives at C-3 Position
    Zheng, Qutong
    Liu, Yi
    Chen, Hongfei
    Xiao, Yan
    Zeng, Xianliang
    Wei, Yun
    Luo, Xinrui
    Xiao, Xuan
    Wang, Zongbao
    Zheng, Xing
    NATURAL PRODUCTS JOURNAL, 2015, 5 (03): : 191 - 198
  • [40] NOVEL C-3 CYCLIC ETHER CEPHALOSPORINS AND THEIR ORALLY ABSORBED PRODRUG ESTERS
    BATESON, JH
    BURTON, G
    FELL, SCM
    SMULDERS, HC
    JOURNAL OF ANTIBIOTICS, 1994, 47 (02): : 253 - 256
12345