SYNTHESIS OF CEPHALOSPORINS HAVING A HETEROCYCLIC GROUP AT THE C-3 POSITION

被引：0
|
作者：
JUNG, MH [1 ]
CHO, KW [1 ]
KIM, WJ [1 ]
SHIN, JS [1 ]
PARK, CS [1 ]
机构：
[1] YUNGJIN PHARM CO LTD,KYUNGGI-DO 456860,SOUTH KOREA
来源：
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 1993年 / 14卷 / 01期
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
3-(3-Bromotetrahydrofuran-2-yl)-3-cephem 7 was obtained from 3-(2-hydroxyethyl)vinyl-3-cephem 6 by the cyclization reaction using N-bromosuccinimide. Compound 5 was prepared by Wittig reaction, namely a coupling of cephem-derived triphenylphosphonium salt 3 with aldehyde component 4 in the presence of base.
引用
收藏
页码：32 / 34
页数：3
相关论文
共 50 条
  • [1] SYNTHESIS OF A NEW SERIES OF CEPHALOSPORINS HAVING 3-SUBSTITUTED-AMMONIO-1-PROPENYL GROUP AS THE C-3 SIDE-CHAIN
    KAMACHI, H
    OKA, M
    NARITA, Y
    IIMURA, S
    ABURAKI, S
    YAMASHITA, H
    TOMATSU, K
    OKUMURA, J
    NAITO, T
    JOURNAL OF ANTIBIOTICS, 1990, 43 (05): : 533 - 543
  • [2] NOVEL CEPHALOSPORINS HAVING A BENZOTHIOPYRAN GROUP .2. SYNTHESIS AND BIOLOGICAL-ACTIVITY OF CATECHOLIC BENZOTHIOPYRAN GROUP AT THE C-3 SIDE-CHAIN
    OBI, K
    SAITO, T
    KOJIMA, A
    FUKUDA, H
    HIRAI, K
    SUZUE, S
    JOURNAL OF ANTIBIOTICS, 1995, 48 (03): : 278 - 281
  • [3] Synthesis and antibacterial activity of novel cephalosporins containing 2,3-disubstituted-1,8-naphthyridiniummethyl group at the C-3 position
    Ju, H
    Im, SK
    Jeon, JM
    Kang, JS
    Kim, DU
    Cho, SK
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2005, 26 (11) : 1669 - 1670
  • [4] SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF C-3' ISOTHIAZOLYL AND RELATED CEPHALOSPORINS
    SKOTNICKI, JS
    STRIKE, DP
    JOURNAL OF ANTIBIOTICS, 1986, 39 (03): : 380 - 383
  • [5] SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF C-3' ISOTHIAZOLYL AND RELATED CEPHALOSPORINS
    SKOTNICKI, JS
    STRIKE, DP
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1986, 191 : 74 - MEDI
  • [6] NOVEL CEPHALOSPORINS HAVING A BENZOTHIOPYRAN GROUP .1. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF CEPHALOSPORIN DERIVATIVES CHARACTERIZED BY NOVEL C-3 SUBSTITUENTS OF BENZOTHIOPYRAN
    OBI, K
    SAITO, T
    FUKUDA, H
    HIRAI, K
    SUZUE, S
    JOURNAL OF ANTIBIOTICS, 1995, 48 (03): : 274 - 277
  • [7] Synthesis and in vitro antibacterial activity of cephalosporins with a pyridinium substituent carrying an isoxazole moiety at the C-3 position
    Park, H
    Choi, H
    Jang, J
    Choi, S
    Rhee, J
    Chang, M
    ARCHIVES OF PHARMACAL RESEARCH, 2001, 24 (02) : 89 - 94
  • [8] Cephalosporins with the dichlorophenyl group at C-7 position and pyrimidines at C-3 position exhibiting potent activity against gram-positive strains
    Kim, GT
    Ryu, EJ
    Tang, YJ
    Lee, CS
    Youn, H
    Cho, YR
    Joo, HY
    JOURNAL OF ANTIBIOTICS, 2004, 57 (07): : 468 - 472
  • [9] Synthesis andin vitro antibacterial activity of cephalosporins with a pyridinium substituent carrying an isoxazole moiety at the C-3 position
    Haeil Park
    Hyunjoo Choi
    Jinhee Jang
    Sunghak Choi
    Jaekeol Rhee
    Minsun Chang
    Archives of Pharmacal Research, 2001, 24 : 89 - 94
  • [10] Heterotactic polymerization of methacrylates having C-3 ester group
    Osaka Univ, Osaka, Japan
    Polym J, 9 (767-769):
12345