SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME NEW PYRIDYL DIARYLSULFIDE AND DIARYLSULFONES

Condensation of isonicotinaldehyde with 4-aminodiphenyl sulfides I and/or sulfones II gave 4-[N-[p-(diaryl/thio)]formimidoyl]-pyridine III and/or 4-[N-[p-(diarylsulfonyl)]-formimidoyl]pyridine IV. Cyclocondensation of mercaptoacetic acid on III and IV gave 3-[p-(diarylthio)]-2-(4-pyridyl)-4-thiazolidinones V and 3-[p-(diarylsulfonyl)]-2-(4-pyridyl)-4-thiazolidinones VI respectively. (Hetero/arylthio)-N-(6-methyl-2-pyridyl)-acetamides VIII have been synthesised via interaction of 6-methyi-2-chloroacetamido-pyridine VII with heterocyclic and/or aromatic mercaptans. Reaction of VII with piperidine and/or morpholine affords (IX). Biological activities of these compounds were tested. © 1990, Taylor & Francis Group. All rights reserved.